Category: 292636-12-5

Owa, Takashi’s team published research in Yuki Gosei Kagaku Kyokaishi in 2006 | CAS: 292636-12-5

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C8H7ClN2

Electric Literature of C8H7ClN2On November 30, 2006 ,《Chemistry and biology of a series of antitumor sulfonamides: exploiting transcriptomic and quantitative proteomic analyses for exploring drug gable chemical space》 appeared in Yuki Gosei Kagaku Kyokaishi. The author of the article were Owa, Takashi. The article conveys some information:

Sulfolnamide-focused compound libraries have been synthesized in our laboratories for biol. evaluation using antitumor phenotypic screens such as cancer cell proliferation assay, flow cytometric cell cycle anal., and rat aorta tube formation assay. Among thousands of sulfonamide compounds evaluated, E7010 (a microtubule depolymerizing agent), E7070 (a G1 phase cell cycle inhibitor), and E7820 (an antiangiogenesis agent) have progressed to clin. trials, thereby demonstrating some objective responses in cancer patients so far. The sequential discovery of these drug candidates allowed us to carry out a research approach of forward chem. genetics, in which phenotypically bioactive compounds are selected from a large collection of small mols. and then utilized for understanding the functions of their protein partners and relevant biol. pathways via target identification. This paper describes our attempt using oligonucleotide microarray and quant. proteomic analyses not only for identifying drug targets and downstream pathways applicable to biomarkers but also for exploring drug gable chem. space in medicinal chem. research. In the experiment, the researchers used many compounds, for example, 4-Chloro-1H-indol-7-amine(cas: 292636-12-5Electric Literature of C8H7ClN2)

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C8H7ClN2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Owa, Takashi’s team published research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 292636-12-5

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4-Chloro-1H-indol-7-amine

Name: 4-Chloro-1H-indol-7-amineOn June 5, 2000, Owa, Takashi; Okauchi, Tatsuo; Yoshimatsu, Kentaro; Sugi, Naoko Hata; Ozawa, Yoichi; Nagasu, Takeshi; Koyanagi, Nozomu; Okabe, Tadashi; Kitoh, Kyosuke; Yoshino, Hiroshi published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors》. The article mentions the following:

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore, e.g. I, was synthesized and evaluated as a potential antitumor agent. Cell cycle anal. with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. The structure-activity relationships of the substituent patterns on this pharmacophore template are described. In the experimental materials used by the author, we found 4-Chloro-1H-indol-7-amine(cas: 292636-12-5Name: 4-Chloro-1H-indol-7-amine)

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4-Chloro-1H-indol-7-amine

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Owa, Takashi’s team published research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 292636-12-5

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4-Chloro-1H-indol-7-amine

Name: 4-Chloro-1H-indol-7-amineOn June 5, 2000, Owa, Takashi; Okauchi, Tatsuo; Yoshimatsu, Kentaro; Sugi, Naoko Hata; Ozawa, Yoichi; Nagasu, Takeshi; Koyanagi, Nozomu; Okabe, Tadashi; Kitoh, Kyosuke; Yoshino, Hiroshi published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors》. The article mentions the following:

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore, e.g. I, was synthesized and evaluated as a potential antitumor agent. Cell cycle anal. with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. The structure-activity relationships of the substituent patterns on this pharmacophore template are described. In the experimental materials used by the author, we found 4-Chloro-1H-indol-7-amine(cas: 292636-12-5Name: 4-Chloro-1H-indol-7-amine)

4-Chloro-1H-indol-7-amine(cas: 292636-12-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4-Chloro-1H-indol-7-amine

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles