With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30448-16-9,7-Methyl-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
The bispyridine ester amine compound (200 mg, 0.99 mmol) in Example 1 and 7-methyl-1H-indole-3-carboxylic acid (170 mg, 0.99 mmol) were dissolved in DMF (5 ml), DCC (230 mg, 1.09 mmol) was added to the solution, and then the mixture was stirred at 80 C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (30 ml, 7%) by chromatography (methanol:dichloromethane=1:30)., 30448-16-9
30448-16-9 7-Methyl-1H-indole-3-carboxylic acid 14810856, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; US2009/258876; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles