Category: 310886-79-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.310886-79-4,Methyl 5-fluoro-1H-indole-3-carboxylate,as a common compound, the synthetic route is as follows.

Example 169; 5 -Fluoro- 1 – |Y4-methyl-2-pyridin-2-y l-pyrimidine-5 -carbonyP-amino] – 1 H-indole-3 -carboxylic acid; Step 1 : A solution of 5-fluoro- lH-indole-3-carboxylic acid methyl ester (510 mg, 2.6 mmol) in NMP (6.5 rnL) at rt is treated with KOt-Bu (342 mg, 2.9 mmol) and stirred at rt for 0.5 h. A solution of O-amino-4-nitrobenzoic acid (558 mg, 3.0 mmol) in NMP (2.5 mL) is added and the mixture is stirred for 3 h. The mixture is diluted with EtOAc (50 mL) and washed with 10% aqueous NaHCO3 (50 mL). The organic layer is separated, dried (Na2SO4), filtered and concentrated in vacuo to afford l-amino-5-fluoro-lH-indole-3-carboxylic acid methyl ester, which is used in the next step without further purification., 310886-79-4

As the paragraph descriping shows that 310886-79-4 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/121670; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.310886-79-4,Methyl 5-fluoro-1H-indole-3-carboxylate,as a common compound, the synthetic route is as follows.

A solution of thallium tris(trifmoroacetate) (8.45 g, 15.6 mmol) in TFA (35 mL) was added to a solution of 5-fluoro-li7-indole-3-carboxylic acid methyl ester (2 g, 10.4 mmol) in TFA (10 mL) at room temperature and stirred for 2 h. The reaction mixture was evaporated in vacuo and the resulting residue suspended in water (25 mL) before being treated with a solution of potassium iodide (5.2 g, 31.3 mmol) in water (50 mL). The reaction mixture was treated with dichloromethane (100 mL) and methanol (5 mL) and the resulting precipitate removed by filtration through celite.The organic layer was separated, washed successively with sodium thiosulfate solution and brine, then dried (MgSO4) and evaporated in vacuo. The resultant material was dissolved in methanol (60 mL) and treated with 40% aqueous NaOH solution (60 mL) then refiuxed for 2 h. The reaction mixture was cooled and extracted with DCM/MeOH (ratio 95:5), dried (MgSO4), filtered and evaporated in vacuo to give a crude solid. Purification by column chromatography gave 5-fluoro-4-iodo-li/1- indole as a pale brown solid (1.05 g, 39 %).NMR deltaH (300 MHz, CDCl3) 6.49-6.52 (m, IH), 6.95 (apparent dt, J = 0.4, 8.6, IH), 7.26-7.33 (m, 2H) and 8.35 (s, IH)., 310886-79-4

As the paragraph descriping shows that 310886-79-4 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

310886-79-4, Methyl 5-fluoro-1H-indole-3-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.384 g (12 [MMOL)] of sodium hydride, at 75% by mass in liquid petroleum jelly, is added at a temperature in the region of [20C] under an argon atmosphere to a solution of 2.26 g [(11.] 7 [MMOL)] of [5-FLUORO-3-METHOXYCARBONYL-1] [H-INDOLE] in 60 cm3 of dimethylformamide. After stirring at a temperature in the region [OF 40C] for 0.5 hour, 1.98 g (12 [MMOL)] of 4-chloroquinoline are added. After stirring at a temperature in the region of [120C] for 6 hours, the reaction mixture is poured into 200 cm3 of water and extracted with 200 cm3 of ethyl acetate. The organic phase is washed with 3 times 100 cm3 of water and is then dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2.7 kPa) to give 3. 5 g of a brown solid which is purified by silica gel chromatography (eluent : dichloromethane). After concentrating the fractions under reduced pressure, 1. 6 g of [5-FLUORO-3-] [METHOXYCARBONYL-1-(QUINOL-4-YL)-1 H-INDOLE] are obtained in the form of a beige-coloured solid [MELTING AT 172C.], 310886-79-4

Big data shows that 310886-79-4 is playing an increasingly important role.

Reference£º
Patent; AVENTIS PHARMA DEUTSCHLAND GMBH; WO2004/7480; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles