With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.312314-26-4,4-(Benzyloxy)-6-fluoro-1H-indole,as a common compound, the synthetic route is as follows.
To a solution of compound l-5b (559 mg, 2.32 mmol) in 70 mL ether, oxalyl chloride was added slowly at O C. After 10 min, the reaction mixture was warmed to room temperature and stirred for 6 h. After the mixture was cooled to O C, Et3N (3.0 mL) and MeOH (3.0 mL) were introduced and the resulting mixture was stirred overnight. The reaction mixture was diluted with water and extracted with EtOAc 2 X 100 mL, the combined organic phase was washed by brine and dried over Na2SO4. After concentration, the crude product 26-1 was obtained as a brown oil (897 mg), which was used in the next step without purification. 1H NMR (CDCl3, 300 MHz) delta (ppm): 9.09 (bs, 1H), 8.00 (d, J=3.0Hz, 1H), 7.50 (d, J=7.1Hz, 2H), 7.28-7.41 (m, 3H), 6.72 (dd, J=1.9, 8.3Hz, 1H), 6.51 (dd, J=1.9, 11.7Hz, 1H), 5.20 (s, 2H), 3.67 (s, 3H)., 312314-26-4
312314-26-4 4-(Benzyloxy)-6-fluoro-1H-indole 10610125, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; GALENEA CORPORATION; ELDER, Amy; HARRIMAN, Geraldine; LEIT, Silvana; LI, Jie; SARD, Howard; ZHANG, Yiliang; WILSON, Doug; WO2011/19738; (2011); A1;,
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