Category: 31241-19-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

(1) 2,3,3-trimethyl-5-methoxy-3H-indole (I4e) (1 mol), the bromoethanol (3 mol) was placed together in 20 mL of dry toluene and heated under reflux for 12 hours under nitrogen, cooled to room temperature, washed with anhydrous diethyl ether and recrystallized from acetone to give a white-yellow solid quaternary ammonium salt (I6d), after drying, store it for later use

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Patent; Shenzhen University; Yang Zhigang; Qu Junle; (65 pag.)CN110128843; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

31241-19-7, General procedure: In parallel, substituted hydrazines 1 (4.0 g, 22.25 mmol) were reacted with 3-methylbutanone(3 mL, 28.04 mmol) in acetic acid and heated to a 100 C for 24 h. The solution was then neutralizedusing sodium bicarbonate and extracted using dichloromethane; affording substituted indolenineheterocycles 2 which was dried under reduced pressure. The heterocycles 2 were then reacted withan alkyl halide in acetonitrile at 100 C for 12-18 h. The quaternary ammonium salts 3 were precipitatedwith diethyl ether, and collected.

The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Levitz, Andrew; Marmarchi, Fahad; Henary, Maged; Molecules; vol. 23; 2; (2018);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.,31241-19-7

General procedure: 2,3,3-Trimethylindolenine (1 g, 12.56 mmol), acetonitrile (50 mL),and methyl idodide (0.94 mL, 15.072 mmol) were refluxed at 80 C for 7 h. The resulting pink precipitate was filtered and washed with ice-cooled chloroform. Yield: 37%.

As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Kim, Bo Hyung; Park, Se Woong; Lee, Donghyun; Kwon, I. I. Keun; Kim, Jae Pil; Bulletin of the Korean Chemical Society; vol. 35; 8; (2014); p. 2453 – 2459;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2,3,3-trimethyl-3H-indole and 3-(bromopropyl)benzene were refluxed for 72h. The reaction was cooled to room temperature, poured into cold ether, and the precipitate was filtered; mp 156-158C, 86% yield;

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Levitz, Andrew; Ladani, Safieh Tork; Hamelberg, Donald; Henary, Maged; Dyes and Pigments; vol. 105; (2014); p. 238 – 249;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

General procedure: In parallel, substituted hydrazines 1 (4.0 g, 22.25 mmol) were reacted with 3-methylbutanone(3 mL, 28.04 mmol) in acetic acid and heated to a 100 C for 24 h. The solution was then neutralizedusing sodium bicarbonate and extracted using dichloromethane; affording substituted indolenineheterocycles 2 which was dried under reduced pressure. The heterocycles 2 were then reacted withan alkyl halide in acetonitrile at 100 C for 12-18 h. The quaternary ammonium salts 3 were precipitatedwith diethyl ether, and collected.

31241-19-7, The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Levitz, Andrew; Marmarchi, Fahad; Henary, Maged; Molecules; vol. 23; 2; (2018);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

EXAMPLE II Under an inert hydrogen or argon atmosphere 1.4 ml of 1M solution of BBr3 in dichloro-methane is added to a solution of 1.2 10-3 mole of 5-methoxy 2,3,3-trimethyl indolenine in 1.5 ml dichloromethane at 0 C. under stirring so as to obtain 5-hydroxy 2,3,3-trimethyl-indolenine.

31241-19-7, The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Essilor International (Compagnie Generale d’Optique; US5114621; (1992); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

General procedure: In parallel, substituted hydrazines 1 (4.0 g, 22.25 mmol) were reacted with 3-methylbutanone(3 mL, 28.04 mmol) in acetic acid and heated to a 100 C for 24 h. The solution was then neutralizedusing sodium bicarbonate and extracted using dichloromethane; affording substituted indolenineheterocycles 2 which was dried under reduced pressure. The heterocycles 2 were then reacted withan alkyl halide in acetonitrile at 100 C for 12-18 h. The quaternary ammonium salts 3 were precipitatedwith diethyl ether, and collected., 31241-19-7

31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Article; Levitz, Andrew; Marmarchi, Fahad; Henary, Maged; Molecules; vol. 23; 2; (2018);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 6b: 5-methoxy-1,2,3,3-tetramethylindoleninium iodide. A mixture of 5-methoxy-2,3,3-trimethylindolenine (17 g, 0.095 mole) and methyl iodide (16.1 g, 0.114 mole) in benzene (120 ml) was heated in an autoclave at 70C for 16 hours. The precipitate was filtered off, washed with benzene and crystallized in methanol (70 ml) and benzene (70 ml). A light-brown powder (21.0 g, 67%) was thus obtained.

31241-19-7, 31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Corning S.A.; EP1044978; (2000); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

5-Methoxy-2,3,3-trimethyl-3H-indole (2 g, 10.6 mmol) and 1-bromobutane (4.3 g, 31.7 mmol) were dissolved in 60 mL acetonitrile and warmed to 75 C The reaction was refluxed for 50 h. After the reaction was completed, it was filtered to give a brown oily liquid (2.1 g,Yield 61.0%,After purification by column chromatography, 2-2 1.5 g of pale yellow solid was obtained.

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Patent; Shenyang Pharmaceutical University; Wang Dun; Wang Yongjun; Yang Xiaoguang; Lv Qingzhi; (25 pag.)CN108752319; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.,31241-19-7

5-Methoxy-2,3,3-trimethyl-3H-indole 12 g (0,063 mol) was dissolved in toluene (20 ml), condenser was attached to the flask and acethyl chloride 9 ml (p=1.104 g/Ml, 9,94 g) was added dropwise. After cooling the mixture to ambient temperature, the mixture was stored at 5 C. for 12 h. Formed crystals were filtered, washed with acetone and cold ether. Yield is 6.6 g of indolium chloride (46.12%) as yellowish crystals. M.p. 201-203 C. 1H NMR (400 MHz, DMSO-D6): delta 1.45 (s, 6H, 2*CH3), 2.62 (s, 3H, 2-CH3), 3.82 (s, 3H, 5-OCH3), 7.02 (dd, J=8.8 Hz, J=2.4 Hz, 1H, 6-H), 7.37 (d, J=2.4 Hz, 1H, 4-H), 7.54 (d, J=8.4 Hz, 1H, 7-H). 13C BMR (100 MHz, DMSO-D6): delta 14.3, 22.0 (2*C), 53.8, 55.9, 109.4, 113.9, 117.2, 134.9, 145.3, 159.7, 193.0. IR (KBr), nu (cm-1): 3134 (N-H), 3021, 2973, 1623, 1479, 1404, 1289, 1022, 797.

The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; KAUNAS UNIVERDITY OF TECHNOLOGY; SACKUS, Algirdas; Marynaitis, Vytas; Krikstolaityt, Sonata; Ragaite, Greta; Vengris, Mikas; (12 pag.)US2017/355709; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles