Category: 31241-19-7

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 2 in dichloromethane (30 mL) at 0 C was added dropwise 2 equivalents of 1 M BBr3 in dichloromethane and the mixture was stirred at room temperature for 12 h. Upon the completion of reaction as monitored by thin layer chromatography (TLC), the reaction mixture was washed with saturated aqueoussolution of sodium bicarbonate and the organic extracts were driedover Na2SO4, filtered, and evaporated to afford 3 as a brown solid in79% yield

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Saikiran, Maryala; Sato, Daisuke; Pandey, Shyam S.; Ohta, Takeshi; Hayase, Shuzi; Kato, Tamaki; Dyes and Pigments; vol. 140; (2017); p. 6 – 13;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Following a modified procedure [22], to a mixture of various substituted 2,3,3-trimethylindole (7.0 mmol), 2-formylpyrrole (1.78 g, 14 mmol), piperidine (12 mL,14 mmol) and ice acetic acid (16.5 mL, 21 mmol) in toluene (50 mL) were addedunder a Dean-Stark trap condition and the mixture was refluxed for 3 h. Thecompletion of the reaction was confirmed by TLC. The brown dark reaction mixturewas cooled, concentrated and separated by column chromatography. The correspondingproducts NDABs as a solid were obtained., 31241-19-7

As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Li, Yujiao; Yan, Jiaying; Cheng, Kai; Kong, Shuai; Zheng, Kaibo; Wang, Long; Zhang, Nuonuo; Research on Chemical Intermediates; vol. 43; 10; (2017); p. 5337 – 5344;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.70 g (9.00 mmol) of 2,3,3-trimethyl-6-methoxyindole 1 were weighed and 2.61 g (18.0 mmol) of 2-formylbenzopyrrole was weighed and 0.15 L of a toluene solution was measured.Take organic acid 0.24mL, 0.30mL organic base were heated and stirred, refluxed at 120 for 2 hours, dried and filtered to give a yellow compound 3.Take 1.99 g (4.50 mmol) of the above compound 3, take 35 mL of toluene solution and 2.80 mL of triethylamine, add 2.10 mL (17.50 mmol) of boron trifluoride etherate solution dropwise with stirring under electromagnetic agitation and raise the temperature to 120 C.,Condensing reflux 8 hours, TLC point plate test, the product was washed, extracted, dried, rotary evaporation, filtered to give compound 4:, 31241-19-7

31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; China Three Gorges University; Zhang Nuonuo; Li Yujiao; Yan Jiaying; Cheng Kai; Li Dejiang; (12 pag.)CN105925004; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,31241-19-7

5-methoxy-2,3,3-trimethyl-3H-indole (2g, 10.6mmol) with1,4-butyl sultone (4.3 g, 31.7 mmol) was dissolved in 40 mL of toluene.The temperature was raised to 120 C and refluxed for 50 h.After the reaction, the mixture was filtered to give an off-white solid.Purified by column chromatography to give a pale yellow solid2-1 1.9g.

The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Shenyang Pharmaceutical University; Wang Dun; Wang Yongjun; Yang Xiaoguang; Lv Qingzhi; (25 pag.)CN108752319; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A synthetic procedure was based on the literature method [15] with some modifications. A solution of 5-methoxy-2,3,3-trimethyl-3H-indole (0.502 g, 1.60 mmol) and 2-bromoethanol (0.198 g, 2.00 mmol) in MeCN (20 mL) was maintained under N2 and heated under reflux for 1 day. After the mixture was cooled to ambient temperature, the solvent was distilled off under reduced pressure. The resulting solid was recrystallized from CHCl3 (35 mL), then filtered and dried, to afford the targeted compound in high yield (68%)., 31241-19-7

31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Article; Li, Hong; Pang, Meili; Wu, Bianpeng; Meng, Jiben; Journal of Molecular Structure; vol. 1087; (2015); p. 23 – 29;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

Example 1.9 Synthesis of 5-Hydroxy-1,2,3,3-Tetramethyl-3H-Indolium Iodide This compound was prepared by the general synthesis method 1c) from 4.0 g of 5-methoxy-2,3,3-trimethyl-3H-indole, 16 mL of acetic acid and 16 mL of 48% hydrobromic acid solution. Yield (intermediate): 2.45 g of 5-hydroxy-2,3,3-trimethyl-3H-indole (66% of the theoretical). 1.0 g of the intermediate thus obtained was alkylated with 1.66 g of methyl iodide and 10 mL of methanol according to variant 3 under 1b). Yield: 1.36 g of 5-hydroxy-1,2,3,3-tetramethyl-3H-indolium iodide (75% of the theoretical). Melting point: 245-247 C. 1H-NMR (D6-DMSO): delta=1.46 ppm (s, 6H); 2.66 ppm (s, 3H); 3.89 ppm (s, 3H); 6.93 ppm (dd, 3J=9 Hz, 4J=2 Hz, 1H); 7.11 ppm (d, 4J=2 Hz, 1H); 7.67 ppm (d, 3J=9 Hz, 1H); 10.22 ppm (s, exchanges with D2O, 1H). FAB mass spectrum: M+=190.10 (100% rel. intensity), 31241-19-7

31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Sauter, Guido; Braun, Hans-Juergen; Reichlin, Nadia; US2003/79301; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles