Category: 31827-04-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31827-04-0,Methyl 3-hydroxy-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

Acetobromo-alpha-D-galactose 1 (4.00 g, 9.72 mmol), indoxylic acid methyl ester 3(2.00 g, 10.46 mmol) and TBASH (3.55g, 10.46 mmol) were dissolved in biphasic solution of CH2Cl2 (60mL) and 1M K2CO3 (60 mL) that stirred at ambient temperature for 8 hours. The reaction mixture waspoured into a separatory funnel, phases were separated and the aqueous layer was extracted with CH2Cl2(2 x 50 mL). The combined organics were washed with H2O (200 mL) then dried over Na2SO4. Themixture was filtered through a silica gel pad and concentrated under reduced pressure. The residue waschromatographed via silica gel flash column (25-75% gradient EtOAc in hexanes) to afford the titlecompound 4 (3.64 g, 75% yield) as solid brown foam. The product was characterized as follows: Rf = 0.5,(1:1) EtOAc:Hexanes, visualized by KMnO4 stain (white spot); CHN calc. (%): C (55.28), H (5.22), N(2.69); found: (%): C (55.41), H (5.02), N (2.73), which corresponds to the literature.

31827-04-0, 31827-04-0 Methyl 3-hydroxy-1H-indole-2-carboxylate 3446522, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Banasik, Brent; Mai, Tam; Samadpour, Mansour; Letters in Organic Chemistry; vol. 15; 10; (2018); p. 822 – 825;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31827-04-0, Methyl 3-hydroxy-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 184C Methyl 3-isopropoxy-1H-indole-2-carboxylate A solution of potassium tert-butoxide (0.25 g, 2.2 mmol) in DMSO (3 mL) at 0 C. was treated with a solution of Example 184B (0.3 g, 1.57 mmol) in DMSO (5 mL), warmed to room temperature, stirred for 1 hour, treated with 2-bromopropane (0.24 mL, 2.5 mmol), stirred at for 16 hours, and poured into ice/water (30 mL). The precipitate was filtered, washed with water and dried under vacuum at room temperature to provide the desired product (58%). MS (ESI(-)) m/e 232 (M-H)-; 1H NMR (300 MHz, DMSO-d6) delta 1.28 (d, 6H), 3.85 (s, 3H), 4.42-4.52 (m, 1H), 7.04 (t, 1H), 7.25 (t, 1H), 7.36 (d, 1H), 7.59 (d, 1H), 11.30 (s, 1H).

31827-04-0, The synthetic route of 31827-04-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BaMaung, Nwe Y.; Craig, Richard A.; Kawai, Megumi; Wang, Jieyi; Dai, Yujia; Guo, Yan; Sheppard, George; Verzal, Mary K.; Vasudevan, Anil; Michaelides, Michael; US2002/91148; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles