Category: 3189-22-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3189-22-8,7-Methoxyindole,as a common compound, the synthetic route is as follows.

7-methoxyindole (0.2 mmol) was added to a 4 mL reaction flask.1,2-diphenyldisulfide (0.3 mmol),Potassium tert-butoxide (0.4 mmol) and DMF (2.0 mL) were stirred at room temperature. TLC tracks the detection reaction. After 2 hours, the starting material was completely converted.Water and dichloromethane were added to the reaction system, and the organic layer was separated.Wash the water layer twice with dichloromethane, combine all the organic layers, andWash twice with water. The organic layer was dried over anhydrous sodium sulfate, concentrated, and then purified by column chromatography (To the product 32 mg, the yield was 63percent, and the reaction process was as follows:, 3189-22-8

3189-22-8 7-Methoxyindole 76660, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Wenzhou Medical University; Song Zengqiang; Zhan Lingling; Qian Jianchang; Liang Guang; Liu Zhiguo; (14 pag.)CN108586311; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

3189-22-8, 7-Methoxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 7-methoxyindole (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. Benzenesulfonyl chloride (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water/ethyl acetate were added and the ethyl acetate layer was washed repeatedly (3x) with water. The ethyl acetate layer was concentrated and evaporated to dryness., 3189-22-8

The synthetic route of 3189-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNTA PHARAMACEUTICALS CORP.; WO2008/112199; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles