Category: 321-14-2

In an article, author is Jaiswal, Anjali, once mentioned the application of 321-14-2, Name: 5-Chloro-2-hydroxybenzoic acid, Name is 5-Chloro-2-hydroxybenzoic acid, molecular formula is C7H5ClO3, molecular weight is 172.57, MDL number is MFCD00002457, category is indole-building-block. Now introduce a scientific discovery about this category.

An efficient regioselective C-3 acylation of free indoles (N-H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)(2) and KOtBu in DMSO.

If you are interested in 321-14-2, you can contact me at any time and look forward to more communication. Name: 5-Chloro-2-hydroxybenzoic acid.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

321-14-2, Name is 5-Chloro-2-hydroxybenzoic acid, molecular formula is C7H5ClO3, belongs to indole-building-block compound, is a common compound. In a patnet, author is Chang, Guanjun, once mentioned the new application about 321-14-2, Application In Synthesis of 5-Chloro-2-hydroxybenzoic acid.

Enhanced carbon dioxide capture in an indole-based microporous organic polymer via synergistic effects of indoles and their adjacent carbonyl groups

A carbonyl-functionalized indole-based microporous organic polymer (PKIN) was designed and synthesized in the presence of the FeCl3 catalyst by a facile direct oxidative coupling reaction. Taking advantage of the synergistic effect of indoles and their adjacent carbonyl moieties on carbon dioxide (CO2), the CO2 uptake capacity of the polymer reaches up to 6.12 mmol g(-1) (1.0 bar, 273 K) with high gas selectivities, making the polymer a promising microporous material for the application of CO2 separation and capture, and the proposed synergistic effect is expected to be a new rationale for the design of CO2 capture materials.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 321-14-2. The above is the message from the blog manager. Application In Synthesis of 5-Chloro-2-hydroxybenzoic acid.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.321-14-2, Name is 5-Chloro-2-hydroxybenzoic acid, SMILES is O=C(O)C1=CC(Cl)=CC=C1O, belongs to indole-building-block compound. In a document, author is Banari, Hoda, introduce the new discover, Computed Properties of C7H5ClO3.

Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid

In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3′-bis(indolyl) methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is simple and the expected bis-heterocyclic compounds were isolated in good to high yields. The present protocol provides the advantages of convenience, mild reaction conditions, eco-friendliness, energy-saving, and no use of hazardous solvents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 321-14-2 is helpful to your research. Computed Properties of C7H5ClO3.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 321-14-2, Name is 5-Chloro-2-hydroxybenzoic acid, SMILES is O=C(O)C1=CC(Cl)=CC=C1O, in an article , author is Sari, Suat, once mentioned of 321-14-2, Product Details of 321-14-2.

Design, synthesis, antifungal activity, and QM/MM docking study of two azole derivatives with indole ring

Systemic candidiasis is a major health issue for immunocompromised individuals due to the increase in drug-resistance among Candida spp., which are prevalent pathogenic fungi responsible for many types of fungal infections. Azoles are among the most preferred antifungal class for systemic candidiasis with broad antifungal spectrum and systemic availability. In this study, we synthesized and tested antifungal effects of two new indole derivatives to investigate the impact of indole on the activity of azole antifungal compounds and to find potent derivatives against Candida spp. including resistant strains and biofilms. 1-(4-Chlorophenyl)-2-(1H-imidazol-1-yl)ethanol 1H-indole-2-carboxylate (4a) showed excellent antifungal profile with several times more potent activity against the tested species including a fluconazole-resistant C. tropicalis isolate. The minimum inhibitory concentration (MIC) of 4a was 0.03125 mu g/ml against C. albicans, which was 0.5 mu g/ml for fluconazole. The compound also showed promising biofilm inhibitory effect compared to amphotericin B. The importance of indole was demonstrated through molecular docking studies with the structure of C. albicans CYP51, the established target of azole antifungals, using different protocols. QM/MM docking approach yielded excellent results and accuracy, especially regarding metal interactions. As a result, indole could be a very useful fragment to design new and highly potent antifungal compounds in azole structure.

Interested yet? Read on for other articles about 321-14-2, you can contact me at any time and look forward to more communication. Product Details of 321-14-2.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles