344790-96-1, 5-Bromo-4-fluoro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Bromo-4-fluoro-1H-indole obtained by the method described in Eur. J. Org. Chem. 2956-2969, 2006 (793 mg) was dissolved in N,N-dimethylformamide (30 ml), and bis(pinacolato)diboron (1.88 g), potassium acetate (1.82 g) and a [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) chloride-dichloromethane complex (151 mg) were added. The mixture was stirred with heating under nitrogen atmosphere at 100 C. overnight. The reaction solution was cooled to room temperature and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (developed with ethyl acetate-hexane). The resulting colorless oil was slurry washed with hexane to give the title compound (481 mg) as a colorless solid.MS (EI) m/z: 261M+.1H-NMR (CDCl3) delta: 1.38 (12H, s), 6.65-6.68 (1H, m), 7.14-7.17 (1H, m), 7.18 (1H, s), 7.51 (1H, dd, J=8.3, 5.5 Hz), 8.27 (1H, brs).
344790-96-1, The synthetic route of 344790-96-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Daiichi Sankyo Company, Limited; US2011/82138; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles