Category: 380448-07-7

Tois, Jan’s team published research in Journal of Combinatorial Chemistry in 2001 | CAS: 380448-07-7

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Tois, Jan; Franzen, Robert; Aitio, Olli; Laakso, Into; Kylaenlahti, Irene published their research in Journal of Combinatorial Chemistry on December 31 ,2001. The article was titled 《Vilsmeier formylation of 2-carboxyindoles and preparation of O-benzylhydroxyureas on solid phase》.Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid The article contains the following contents:

The Vilsmeier formylation has been introduced for the solid-phase functionalization of five different 2-carboxyindoles, e.g. 2-carboxyindole. The aldehyde functionality has been utilized in the preparation of O-benzylhydroxyureas, e.g. I. In the experimental materials used by the author, we found 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid)

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yoshikawa, Kenji’s team published research in Bioorganic & Medicinal Chemistry in 2009 | CAS: 380448-07-7

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu published their research in Bioorganic & Medicinal Chemistry on December 15 ,2009. The article was titled 《Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties》.Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid The article contains the following contents:

A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clin. candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochem. properties and pharmacokinetic (PK) profiles of some prospective compounds In the experiment, the researchers used 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid)

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Velezheva, Valeriya’s team published research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 380448-07-7

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C10H6ClNO3

Velezheva, Valeriya; Brennan, Patrick; Ivanov, Pavel; Kornienko, Albert; Lyubimov, Sergey; Kazarian, Konstantin; Nikonenko, Boris; Majorov, Konstantin; Apt, Alexander published an article on February 1 ,2016. The article was titled 《Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Synthetic Route of C10H6ClNO3 The information in the text is summarized as follows:

We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and hydrazide-hydrazones combining indole and pyridine nuclei. The compounds are derivatives of 1-acetylindoxyl or substituted indole-3-carboxaldehydes tethered via a hydrazine group by simple C-N or double C:N bonds with 3- and 4-pyridines, 1-oxide 3- and 4-pyridine carbohydrazides. The most active of the 15 compounds showed MICs values against an INH-sensitive strain of Mycobacterium tuberculosis H37Rv equal to that of INH (0.05-2 μg/mL). Five compounds demonstrated appreciable activity against the INH-resistant M. tuberculosis CN-40 clin. isolate (MICs: 2-5 μg/mL), providing justification for further in vivo studies. The results came from multiple reactions, including the reaction of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Synthetic Route of C10H6ClNO3)

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C10H6ClNO3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Downstream synthetic route of 380448-07-7

As the paragraph descriping shows that 380448-07-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.380448-07-7,5-Chloro-3-formyl-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.,380448-07-7

REFERENTIAL EXAMPLE 287 5-Chloro-2-ethoxycarbonylindole-3-carboxylic acid: The compound (1.5 g) obtained in Referential Example 286 and sulfamic acid (1.7 g) were dissolved in tert-butanol (30 ml)-water (30 ml), and sodium chlorite (1.6 g) was added to stir the mixture for 8 hours. The reaction mixture was diluted with water and extracted with ethyl acetate, and the extract was successively washed with 1N hydrochloric acid and saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of isopropyl ether and hexane to obtain the title compound (0.7 g). 1H-NMR (DMSO-d6) delta: 1.34(3H,t,J=7.1 Hz), 4.38(2H,q,J=7.1 Hz), 7.33(1H,dd,J=8.0, 1.4 Hz), 7.52(1H,d,J=8.0 Hz), 7.97(1H,d,J=1.4 Hz), 12.75(1H,br).

As the paragraph descriping shows that 380448-07-7 is playing an increasingly important role.

Reference：
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; US2005/20645; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Some tips on 380448-07-7

380448-07-7, 380448-07-7 5-Chloro-3-formyl-1H-indole-2-carboxylic acid 4714969, aindole-building-block compound, is more and more widely used in various fields.

380448-07-7, 5-Chloro-3-formyl-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Referential Example 287] 5-Chloro-2-ethoxycarbonylindole-3-carboxylic acid: The compound (1.5 g) obtained in Referential Example 286 and sulfamic acid (1.7 g) were dissolved in tert-butanol (30 ml)-water (30 ml), and sodium chlorite (1.6 g) was added to stir the mixture for 8 hours.. The reaction mixture was diluted with water and extracted with ethyl acetate, and the extract was successively washed with 1N hydrochloric acid and saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate.. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of isopropyl ether and hexane to obtain the title compound (0.7 g).1H-NMR (DMSO-d6) delta: 1.34(3H,t,J=7.1Hz), 4.38(2H,q,J=7.1Hz), 7.33(1H,dd,J=8.0,1.4Hz), 7.52(1H,d,J=8.0Hz), 7.97(1H,d,J=1.4Hz), 12.75(1H,br).

380448-07-7, 380448-07-7 5-Chloro-3-formyl-1H-indole-2-carboxylic acid 4714969, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1405852; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles