Chemistry, like all the natural sciences, SDS of cas: 3895-92-9, begins with the direct observation of nature— in this case, of matter.3895-92-9, Name is Chelerythrine Chloride, SMILES is C[N+]1=CC2=C(OC)C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3.[Cl-], belongs to indole-building-block compound. In a document, author is Zhou, Rong, introduce the new discover.
A novel indole alkaloid, misszrtine A (1), was isolated from marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. The planar structure of 1 was assigned by analysis of spectroscopic data, the absolute configuration of which was unambiguously determined by total synthesis. Compound 1 represents the first example of N-isopentenyl tryptophan methyl ester with a phenylpropanoic amide arm, which exhibited a potent antagonistic activity on HL60 (IC50 = 3.1 mu M) and LNCaP (IC50 = 4.9 mu M) cell lines. Bioactivity evaluation reveals that functional group on indole nitrogen of 1 has a great effect on its cytotoxity, which provides a mean to probe the structure-activity relationships of 1.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3895-92-9. SDS of cas: 3895-92-9.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles