With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.398487-76-8,4-Fluoro-2-methyl-1H-indol-5-amine,as a common compound, the synthetic route is as follows.
Step 12f: Ethyl 7-(7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-ylamino)quinazolin-6-yloxy)-heptanoate (compound 601-20) The title compound 601-20 (100 mg, 52%) was prepared as a dark solid from compound 507-20 (150 mg, 0.34 mmol) and 402 (67 mg, 0.41 mmol) using a procedure similar to that described for compound 601-18 (Example 10): LCMS: 571 [M+1]+; 1H NMR (DMSO-d6): delta 11.22 (s, 1H), 9.33 (s, 1H), 8.20 (s, 1H), 7.84 (s, 1H), 7.50 (d, J=8.4 Hz, 2H), 7.43-7.32 (m, 3H), 7.21 (s, 1H), 7.10 (d, J=8.4 Hz, 1H), 6.97 (t, J=8.4 Hz, 1H), 6.19 (s, 1H), 5.29 (s, 2H), 4.11 (t, J=8.7 Hz, 2H), 4.00 (q, J=6.00 Hz, 2H), 2.38 (s, 3H), 2.26 (t, J=7.5 Hz, 2H), 1.82-1.76 (m, 2H), 1.57-1.35 (m, 6H), 1.14 (t, J=7.5 Hz, 3H)., 398487-76-8
The synthetic route of 398487-76-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Qian, Changgeng; Cai, Xiong; Zhai, Haixiao; US2009/76044; (2009); A1;,
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