Category: 399-52-0

《Oxidative dearomative cross-dehydrogenative coupling of indoles with diverse C-H nucleophiles: efficient approach to 2,2-disubstituted indolin-3-ones》 was written by Yan, Xue; Tang, Ying-De; Jiang, Cheng-Shi; Liu, Xigong; Zhang, Hua. SDS of cas: 399-52-0 And the article was included in Molecules in 2020. The article conveys some information:

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles was developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles were demonstrated under the same conditions. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shaikh, Iqbal N.; Rahim, Abdul; Faazil, Shaikh; Adil, Syed Farooq; Assal, Mohamed E.; Hatshan, Mohammad Rafe published an article in 2021. The article was titled 《BF3-OEt2 catalyzed C3-alkylation of indole: synthesis of indolylsuccinimides and their cytotoxicity studies》, and you may find the article in Molecules.Recommanded Product: 5-Fluoro-1H-indole The information in the text is summarized as follows:

A simple and efficient BF3-OEt2 promoted C3-alkylation of indole has been developed to obtain 3-indolylsuccinimides I (R1 = H, OMe, F, Br, CN, NO2; R2 = H, Me, Bn; R3 = Me, Ph, Bn) from com. available indoles II and maleimides III, with excellent yields under mild reaction conditions. Furthermore, anti-proliferative activity of these conjugates was evaluated against HT-29 (Colorectal), Hepg2 (Liver) and A549 (Lung) human cancer cell lines. One of the compounds, I (R1 = H, R2 = R3 = Me), having N,N-Dimethylatedindolylsuccinimide is a potent congener amongst the series with IC50 value 0.02μM and 0.8μM against HT-29 and Hepg2 cell lines, resp., and compound I (R1 = R2 = H, R3 = Bn) was most active amongst the series with IC50 value 1.5μM against A549 cells. Mol. docking study and mechanism of reaction have briefly been discussed. This method is better than previous reports in view of yield and substrate scope including electron deficient indoles. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Recommanded Product: 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Recommanded Product: 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of 399-52-0In 2021 ,《Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa》 appeared in Glycobiology. The author of the article were Shanina, Elena; Siebs, Eike; Zhang, Hengxi; Silva, Daniel Varon; Joachim, Ines; Titz, Alexander; Rademacher, Christoph. The article conveys some information:

The carbohydrate-binding protein LecA (PA-IL) from Pseudomonas aeruginosa plays an important role in the formation of biofilms in chronic infections. Development of inhibitors to disrupt LecA-mediated biofilms is desired but it is limited to carbohydrate-based ligands. Moreover, discovery of drug-like ligands for LecA is challenging because of its weak affinities. Therefore, we established a protein-observed 19F (PrOF) NMR (NMR) to probe ligand binding to LecA. LecA was labeled with 5-fluoroindole to incorporate 5-fluorotryptophanes and the resonances were assigned by site-directed mutagenesis. This incorporation did not disrupt LecA preference for natural ligands, Ca2+ and D-galactose (D-Gal). Following NMR perturbation of W42, which is located in the carbohydrate-binding region of LecA, allowed to monitor binding of low-affinity ligands such as N-acetyl D-galactosamine (D-GalNAc, Kd = 780 ± 97 μM). Moreover, PrOF NMR titration with glycomimetic of LecA p-nitrophenyl β-D-galactoside (pNPGal, Kd = 54 ± 6 μM) demonstrated a 6-fold improved binding of D-Gal proving this approach to be valuable for ligand design in future drug discovery campaigns that aim to generate inhibitors of LecA.5-Fluoro-1H-indole(cas: 399-52-0Application of 399-52-0) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Switchable Skeletal Rearrangement of Dihydroisobenzofuran Acetals with Indoles》 were Li, Guofeng; Yao, Ying; Wang, Zheng; Zhao, Man; Xu, Jiecheng; Huang, Liwu; Zhu, Gongming; Bao, Guangjun; Sun, Wangsheng; Hong, Liang; Wang, Rui. And the article was published in Organic Letters in 2019. Computed Properties of C8H6FN The author mentioned the following in the article:

The switchable skeletal rearrangement for the construction of amino indanones and tetrahydroisoquinolones frameworks had been developed. In the presence of a chiral phosphoric acid catalyst, the reaction gave the amino indanones in high yields and good to excellent ee (85-98%), while the methoxyl substituent at the 5-position of dihydroisobenzofuran acetal selectively gave isoquinolinones products in good to excellent ee (46-98%). Furthermore, DFT calculations were performed to explain the regioselectivity of the switchable transformation pathways. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Copper-Catalyzed Aerobic Oxidative Amination of Indole Derivatives via Single-Electron Transfer》 was written by Zhao, Peizheng; Wang, Ke; Yue, Yuanyuan; Chao, Junli; Ye, Yaqing; Tang, Qinghu; Liu, Jianming. Related Products of 399-52-0 And the article was included in ChemCatChem in 2020. The article conveys some information:

An efficient and clean approach for the oxidative amination of indole derivatives with phenothiazines is developed under copper-catalyzed aerobic conditions. The reaction is carried out via the cross-coupling of indole radical cation and phenothiazine radical in air. This approach offers a new perspective in the application of phenothiazine as a nitrogen group source for C-N bond formation reactions. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Related Products of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Related Products of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Regiospecificity in Ligand-Free Pd-Catalyzed C-H Arylation of Indoles: LiHMDS as Base and Transient Directing Group》 was written by Mohr, Yorck; Renom-Carrasco, Marc; Demarcy, Clement; Quadrelli, Elsje Alessandra; Camp, Clement; Wisser, Florian M.; Clot, Eric; Thieuleux, Chloe; Canivet, Jerome. COA of Formula: C8H6FN And the article was included in ACS Catalysis in 2020. The article conveys some information:

A highly efficient catalyst-base pair for the C-H arylation of free (NH)-indoles in the C-3 position was reported. Ligand-free palladium acetate coupled with lithium hexamethyldisilazide (LiHMDS) catalyzed the regiospecific, i.e. 100% regioselective, C-3 arylation of indoles with high turnover numbers This catalytic system was successfully applied to a wide range of substrates including various functional aryl halides and indolic cores. The unique role of LiHMDS as both a base and unexpected transient directing group was revealed exptl. and elucidated computationally, in line with a Heck-type insertion-elimination mechanism. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0COA of Formula: C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.COA of Formula: C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Organic Letters included an article by Tang, Zhi; Liu, Zhili; Tong, Zhou; Xu, Zhihui; Au, Chak-Tong; Qiu, Renhua; Kambe, Nobuaki. Product Details of 399-52-0. The article was titled 《Cu-Catalyzed Cross-Dehydrogenative Coupling of Heteroaryl C(sp2)-H and Tertiary C(sp3)-H Bonds for the Construction of All-Carbon Triaryl Quaternary Centers》. The information in the text is summarized as follows:

A Cu-catalyzed protocol for cross-dehydrogenative coupling of benzofuranones with quinolines, indoles, carbazoles, and thiophene, which furnishes highly functionalized 3,3-diaryl benzofuranones bearing a three aryl quaternary carbon center at the C3 position in good yields, has been developed. A radical mechanism is proposed. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Product Details of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Product Details of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Rose bengal as photocatalyst: visible light-mediated Friedel-Crafts alkylation of indoles with nitroalkenes in water》 was written by Yu, Zong-Yi; Zhao, Jing-Nan; Yang, Fan; Tang, Xiao-Fei; Wu, Yu-Feng; Ma, Cun-Fei; Song, Bo; Yun, Lei; Meng, Qing-Wei. Electric Literature of C8H6FN And the article was included in RSC Advances in 2020. The article conveys some information:

A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irradiation of visible-light and generated corresponding 3-(2-nitroalkyl)indoles I (R1 = H, 5-F, 6-Me, etc.; R2 = C6H5, 4-FC6H4, 2-thienyl, etc.) in moderate to good yields (up to 87%). In the experiment, the researchers used 5-Fluoro-1H-indole(cas: 399-52-0Electric Literature of C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Electric Literature of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 5-Fluoro-1H-indoleIn 2021 ,《Chemo-, Regio-, and Stereoselective Assembly of Polysubstituted Furan-2(5H)-ones Enabled by Rh(III)-Catalyzed Domino C-H Alkenylation/Directing Group Migration/Lactonization: A Combined Experimental and Computational Study》 appeared in ACS Catalysis. The author of the article were Zhao, Fei; Zhou, Zhi; Lu, Yangbin; Qiao, Jin; Zhang, Xiaoning; Gong, Xin; Liu, Siyu; Lin, Shuang; Wu, Xiaowei; Yi, Wei. The article conveys some information:

Exploring multistep cascade reactions triggered by C-H activation are recognized as appealing, yet challenging. Herein, author disclose a Rh(III)-catalyzed domino C-H coupling of N-carbamoyl indoles and 4-hydroxy-2-alkynoates for the streamlined assembly of highly functionalized furan-2(5H)-ones in which the carbamoyl-directing group (DG) is given a dual role of an auxiliary group and a migrating acylating reagent via the cleavage of stable C-N bonds at room temperature More importantly, the obtained furan-2(5H)-one skeleton could be further functionalized under air in situ via C5-H hydroxylation by simply switching the solvent or additive, providing fully substituted furan-2(5H)-ones with the installation of an alc.-based C5 quaternary carbon center. Detailed exptl. studies and d. functional theory calculations reveal that a Rh(III)-mediated tandem C-H activation/alkyne insertion/DG migration/lactonization accounts for the developed transformation to achieve high functionalities with the observed exclusive selectivity. The potential biol. application of the obtained furan-2(5H)-ones as a class of potent PPARγ ligands further highlights the synthetic utility of the developed methodol. This protocol is endowed with several salient features including efficient multistep cascade triggered by C-H activation, excellent chemo-, regio-, and stereoselectivity, high bond-forming efficiency (e.g., two C-C and two C-O bonds), solvent- or additive-controlled product selectivity. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Recommanded Product: 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles》 was written by Zhang, Ming; Lu, Sicong; Li, Guofeng; Hong, Liang. Safety of 5-Fluoro-1H-indoleThis research focused ontosylaminomethylidene ethoxydihydroisobenzofuran indole trimethylchlorosilane tandem aza Michael addition rearrangement; indolyl tosyl tetrahydroisoquinolinone preparation regioselective. The article conveys some information:

A TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles was developed, which provided an efficient and straightforward access to various tetrahydroisoquinolones in moderate to excellent yields. This process involved the first addition of the indoles to acetals, followed by skeletal rearrangement. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles