Category: 399-52-0

HPLC of Formula: 399-52-0In 2019 ,《Stereoselective Desymmetrization of Cyclohexadienone-Tethered Enones: Efficient Access to Highly Strained Polycyclic Indoles》 appeared in ACS Catalysis. The author of the article were Thopate, Satish B.; Jadhav, Sandip B.; Nanubolu, Jagadeesh Babu; Chegondi, Rambabu. The article conveys some information:

A highly regioselective and stereoselective cascade annulation of indoles with C2-sym. enone tethered-cyclohexadienones provides rapid access to complex indole alkaloid-like scaffolds in high yields. Interestingly, a different reaction course was observed with 3-substituted indoles giving C-2/N annulation products with similar complexity via intramol. aza-Michael addition This desymmetrization approach is highly practical and allows atom-economical synthesis of natural product-like mols. containing several contiguous stereocenters with broad range of substrate scope and high functional-group tolerance. The synthetic utility of the products was demonstrated with various chemoselective, regioselective, and diastereoselective transformations on the highly strained polycyclic indoles to elaborate the value of this tandem reaction. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1H-indole(cas: 399-52-0HPLC of Formula: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2022,Basak, Shubhajit; Paul, Tripti; Punniyamurthy, Tharmalingam published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation》.Formula: C8H6FN The author mentioned the following in the article:

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles was accomplished using a readily available arene at moderate temperature The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications were the important practical features. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Formula: C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《One-pot biocatalytic synthesis of substituted D-tryptophans from indoles enabled by an engineered aminotransferase》 were Parmeggiani, Fabio; Rue Casamajo, Arnau; Walton, Curtis J. W.; Galman, James L.; Turner, Nicholas J.; Chica, Roberto A.. And the article was published in ACS Catalysis in 2019. Product Details of 399-52-0 The author mentioned the following in the article:

D-Tryptophan and its derivatives are important precursors of a wide range of indole-containing pharmaceuticals and natural products. Here, we developed a one-pot biocatalytic process enabling the synthesis of D-tryptophans from indoles in good yields and high enantiomeric excess (91% to >99%). Our method couples the synthesis of L-tryptophans catalyzed by Salmonella enterica tryptophan synthase with a stereoinversion cascade mediated by Proteus myxofaciens L-amino acid deaminase and an aminotransferase variant that we engineered to display native-like activity toward D-tryptophan. Our process is applicable to preparative-scale synthesis of a broad range of D-tryptophan derivatives containing electron-donating or -withdrawing substituents at all benzene-ring positions on the indole group. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1H-indole(cas: 399-52-0Product Details of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Visible-light-induced metal and reagent-free oxidative coupling of sp2 C-H bonds with organo-dichalcogenides: synthesis of 3-organochalcogenyl indoles》 were Rathore, Vandana; Kumar, Sangit. And the article was published in Green Chemistry in 2019. Product Details of 399-52-0 The author mentioned the following in the article:

An unique visible-light-induced method for the organochalcogenation of the sp2 C-H bonds of indoles and aniline was presented using diaryl dichalcogenides (S, Se and Te) and oxygen as an oxidant avoiding a photocatalyst, base, catalyst and reagent in acetone at room temperature This benign protocol allowed one to accessed a wide range of 3-arylselenylindoles, 3-arylthioindoles and even 3-aryltelluroindoles with good to excellent yields. Various functionalities namely, methoxy and halo either on indoles or aryl dichalcogenides showed amenability to the developed reaction. Furthermore, thiocyanation of the sp2 C-H bonds of indoles were accomplished by this visible light induced method. A mechanistic understanding by UV-visible, EPR spectroscopy and cyclic voltammetry suggested that light induced electron transfer from the electron rich arene to oxygen providing an arene radical cation and a superoxide radical anion. Subsequently, reaction of the radical cation with aryl dichalcogenides provided a diaryl chalcogenyl cation which upon removal of protons gave unsym. 3-indolyl aryl chalcogenides. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Product Details of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Product Details of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Green Chemistry included an article by Vaidya, Gargi Nikhil; Fiske, Sneha; Verma, Hansa; Lokhande, Shyam Kumar; Kumar, Dinesh. SDS of cas: 399-52-0. The article was titled 《A micellar catalysis strategy applied to the Pd-catalyzed C-H arylation of indoles in water》. The information in the text is summarized as follows:

A modular and selective C-H arylation of indoles I (R = 5-CN, 5-OCH3, 6-Cl, etc.; R1 = H, Me) following the micellar catalysis approach using the third generation “”designer”” surfactant SPGS-550-M in the presence of 1 mol of [(cinnamyl)PdCl]2 under mild conditions has been described. Thus, access to high value C-3-arylated indoles II [R2 = H, F, MeO, CF3, C(O)Me] and C-2-arylated indoles III (Ar = Ph, 4-fluorophenyl, 2H-1,3-benzodioxol-5-yl) was achieved by fulfilling the “”triple bottom line philosophy”” of green chem. The nature of the phosphine ligand was found to be critical for achieving site-selectivity, DPPF and DPPP being the most effective in promoting the arylation at C3-H and C2-H, resp. The reaction is scalable and offers high chemo- (C vs. N) and regio-selectivity (C-3 vs. C-2) with a wide range of functional group tolerance. The surfactant aqueous solution can be recycled and reused without compromising on product yields. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhou, Su; Liu, Qianqian; Bao, Ming; Huang, Jie; Wang, Junjian; Hu, Wenhao; Xu, Xinfang published an article in 2021. The article was titled 《Gold(I)-catalyzed redox transformation of o-nitroalkynes with indoles for the synthesis of 2,3′-biindole derivatives》, and you may find the article in Organic Chemistry Frontiers.SDS of cas: 399-52-0 The information in the text is summarized as follows:

An efficient and practical methods for the syntheses of 2-indolyl indolone N-oxides I [R = H, Me, CH2CH=CH2; R1 = 4-F, 5-Cl, 6-Me, etc.; R2 = H, 6-Me, 7-F, etc.; R3 = H, Me] and 1’H,3H-[2,3′-biindol]-3-ones II [R4 = H, Ph, Bn, 4-ClPhCH2; R5 = H, 6-Me, 5-F, 7-F ] via gold(I)-catalyzed cascade reaction of o-nitroalkynes with indoles were reported. The generated product could be readily converted into the 2-indolylbenzoxazinone, which emitted strong blue fluorescence. Also some of the compounds I and II evaluated for antitumor activity for small cell lung cancer and the results showed that compounds I [R = H; R1 = 6-Me; R2 = H; R3 = H] and II [R4 = H; R5 = 6-Me] exhibited high anticancer potency against SCLC cells. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Rhodium-Catalyzed Diastereo- and Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines》 was written by Grugel, Christian P.; Breit, Bernhard. HPLC of Formula: 399-52-0This research focused onvinylic spiroindoline preparation enantioselective diastereoselective rhodium catalyst; allenylindole spirocyclization reduction. The article conveys some information:

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction’s synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0HPLC of Formula: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wan, Xiao; Sun, Meng; Wang, Jing-Yi; Yu, Lei; Wu, Qiong; Zhang, Yu-Chen; Shi, Feng published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Regio- and enantioselective ring-opening reaction of vinylcyclopropanes with indoles under cooperative catalysis》.SDS of cas: 399-52-0 The article contains the following contents:

The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products I [R = CH(CN)2, CH(C(O)2Et)2; R1 = 2-Me, 5-Br, 7-F, etc.; R2 = H, Me] with branched selectivity in moderate yields (up to 78%) and good enantioselectivities (up to 97 : 3 er). This reaction not only represents the first catalytic asym. ring-opening reaction of vinylcyclopropanes like 1,1-dicyano-2-vinylcyclopropane and 1,1-di-Et 2-ethenyl-1,1-cyclopropanedicarboxylate with C3-unsubstituted indoles II, but also has provided an atom-economic and straightforward method for the synthesis of C3-allylic indoles I with high regio- and enantioselectivity. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Man; Xiang, Qirui; Si, Wen; Song, Ran; Yang, Daoshan; Li, Ming; Lv, Jian published an article in 2021. The article was titled 《Bioinspired cyclization of in situ generated γ-indolyl β,γ-unsaturated α-keto esters via an oxidative enamine process: facile approaches to pyrano[2,3-b]indoles》, and you may find the article in Organic Chemistry Frontiers.Quality Control of 5-Fluoro-1H-indole The information in the text is summarized as follows:

A bioinspired cyclization of in-situ generated γ-indolyl β,γ-unsaturated α-ketoesters with an oxoammonium salt via an oxidative enamine process was developed. Under mild conditions, the reactions afforded pyrano[2,3-b]indoles, which are found in a wide range of bioactive compounds, in good yields (up to 86% yield). The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Quality Control of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Quality Control of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Leveille, Alexandria N.; Echemendia, Radell; Mattson, Anita E.; Burtoloso, Antonio C. B. published their research in Organic Letters in 2021. The article was titled 《Enantioselective Indole Insertion Reactions of α-Carbonyl Sulfoxonium Ylides》.Safety of 5-Fluoro-1H-indole The article contains the following contents:

The first example of organocatalytic enantioselective C-H insertion reactions of indoles and sulfoxonium ylides is reported. Under the influence of phosphoric acid catalysis, levels of enantiocontrol in the range of 20-93% ee and moderate yields (up to 50%) were achieved for 29 examples in formal C-H insertion reactions of indoles and α-carbonyl sulfoxonium ylides. No nitrogen protection on the indole is necessary. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Safety of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles