408355-23-7, 7-Bromo-5-fluoro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,408355-23-7
Combine N-(2-(lH-l,2,3-triazol-l-yl)ethyl)-5-fluoro-4-(7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)benzo[b]thiophen-2-yl)pyrimidin-2-amine (0.12 g, 0.26 mmol), 7-bromo-5-fluoro-lH-indole (64 mg, 0.28 mmol, synthesized based on reference: Manfred S.; Assunta G.; Frederic L., Eur. J. Org. Chan. 2006, 2956- 2969), barium hydroxide octahydrate (0.24 g, 0.77 mmol, alternatively sodium carbonate, potassium carbonate, cesium fluoride), Pd(dppf)Ci2 (20 mg, 0.03 mmol) in 2 mL of mixed solvent of DMF (alternatively dioxane, DMSO) and water (4/1, v/v). Purge the mixture with nu2 three times. Heat the reaction mixture to 80 0C for 4 h (HPLC monitor) (or microwave reactor). Cool to RT. Dilute with chloroform/IPA (3: 1, v/v) 50 mL. Wash with water, aqueous saturated sodium chloride and dry over magnesium sulfate. Remove the organic solvent to give the crude product. Purify the residue by column chromatography (hexane to ethyl acetate, or methylene chloride and methanol) to give the title compound (0.053 g, 43 %). MS (ES) m/z 474 [M+ 1]+.
408355-23-7 7-Bromo-5-fluoro-1H-indole 3852879, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144223; (2008); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles