Category: 4264-35-1

4264-35-1, Name is 1-(1H-Indol-2-yl)ethanone, belongs to indole-building-block compound, is a common compound. 4264-35-1. In an article, authors is Akimoto, Hiroshi, once mentioned the new application about 4264-35-1.

Synthesis of 3-Amino-5H-pyrido<4,3-b>indoles, Carcinogenic gamma-Carbolines

The carcinogenic gamma-carbolines 3-amino-1,4-dimethyl-5H-pyrido<4,3-b>indole (1) and 3-amino-1-methyl-5H-pyrido<4,3-b>indole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-gamma-carbolines.This was followed by dehydrogenation to the gamma-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of gamma-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-<1-(dimethylamino)alkyl>indoles.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4264-35-1, Name is 1-(1H-Indol-2-yl)ethanone, belongs to indole-building-block compound, is a common compound. 4264-35-1. In an article, authors is Akimoto, Hiroshi, once mentioned the new application about 4264-35-1.

Synthesis of 3-Amino-5H-pyrido<4,3-b>indoles, Carcinogenic gamma-Carbolines

The carcinogenic gamma-carbolines 3-amino-1,4-dimethyl-5H-pyrido<4,3-b>indole (1) and 3-amino-1-methyl-5H-pyrido<4,3-b>indole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-gamma-carbolines.This was followed by dehydrogenation to the gamma-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of gamma-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-<1-(dimethylamino)alkyl>indoles.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4264-35-1

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4264-35-1, 1-(1H-Indol-2-yl)ethanone is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4264-35-1

5-Chloro-2-hydroxy-N’-((1E)-1-(1H-indol-2-yl)ethylidene)benzohydrazide (6t) To a mixture of methyl 5-chloro-2-hydroxybenzoate (162 mg, 0.87 mmol) in isobutanol (0.5 mL) was added hydrazine hydrate (42 muL, 0.87 mmol). The reaction mixture was irradiated with microwaves for 15 min at 115 C. Isobutanol was added and the supernatant was removed. The residue was taken up in isobutanol (0.5 mL) and 1-(1H-indol-2-yl)ethanone 3p (138 mg, 0.87 mmol) was added. The reaction mixture was again irradiated with microwaves for 10 min at 110 C. The solid product was filtered and then, triturated with EtOH and Et2O to afford 6t as a yellow solid (90 mg, 33%). Mp = 198-200 C. 1H NMR (400 MHz, DMSO-d6): delta 12.46 (s, 1H), 11.39 (s, 1H), 10.07 (s, 1H), 7.86 (d, J = 2.4 Hz, 1H), 7.60 (d, J = 7.6 Hz, 1H), 7.47 (d, J = 7.6 Hz, 1H), 7.41 (dd, J = 8.8 Hz, 2.4 Hz, 1H), 7.19 (tm, J = 7.6 Hz), 7.03 (m, 2H), 6.93 (d, J = 8.8 Hz, 1H), 2.48 (s, 3H). 13C NMR (100 MHz, DMSO-d6): delta 158.0, 153.8, 137.5, 136.5, 132.8, 127.7, 126.8, 123.4, 122.3, 120.9, 119.3, 119.1, 111.8, 104.9, 14.5. HRMS calcd for (C17H1435ClN3O2+Na)+ 350.0663, found 350.0667.

4264-35-1 1-(1H-Indol-2-yl)ethanone 589081, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Kumar, Nag S.; Amandoron, Emily A.; Cherkasov, Artem; Brett Finlay; Gong, Huansheng; Jackson, Linda; Kaur, Sukhbir; Lian, Tian; Moreau, Anne; Labriere, Christophe; Reiner, Neil E.; See, Raymond H.; Strynadka, Natalie C.; Thorson, Lisa; Wong, Edwin W.Y.; Worrall, Liam; Zoraghi, Roya; Young, Robert N.; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7069 – 7082;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles