Category: 434958-85-7

434958-85-7,434958-85-7, N-Boc-5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound III-2 (3.2 g, 13.7 mmol)Was dissolved in 20 mL of CH2Cl2,Diisopropylethylamine (1.77 g, 13.7 mmol)Was dissolved in 120 mL of tetrahydrofuran,Mixed with both,The mixed solution was then slowly added to triphosgene (1.3 g, 4.38 mmol)In CH2Cl2 (100 mL)After stirring at room temperature for 1 h,A mixture of 1,4-diazabicyclo [3.2.2] nonane (1.72 g, 13.7 mmol)Of the CH2Cl2 solution was slowly added thereto,Reaction at room temperature for 4 h;After completion of the reaction, add H2O dilution withCHCl3, the organic phase was collected, washed with saturated aqueous NaCl solution, dried over anhydrous Na2SO4, the solvent was removed to give the crude product;CHCl3 and CH3OH (90:10) as the developing solvent. The product III-3 (2.4 g, 45%) was isolated.

434958-85-7 N-Boc-5-Hydroxyindole 22596220, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Beijing Normal University; Zhang Huabei; Wang Huan; Fang Yu; Liu Jianping; Wang Shuxia; (32 pag.)CN107188900; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

434958-85-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.434958-85-7,N-Boc-5-Hydroxyindole,as a common compound, the synthetic route is as follows.

Example 93C; 5 -[4-(4-Bromo-phenylcarbamoyl)-2-nitro-phenoxy]-indole- 1-carboxylic acid tert-butyl ester; [0465] The products of Example 1OA (406.5 mg, 1.145 mmol) and Example 93B (267 mg, 1.145 mmol) were dissolved in anhydrous N,N-dimethylformamide (8 mL), treated with potassium carbonate (316 mg, 2.289 mmol), and heated at 80 under a nitrogen atmosphere for 3 hours. The reaction was cooled to room temperature and the solvent removed by rotary evaporation under vacuum. The residue was taken up in water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic extracts were washed with brine (25 mL), dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation under vacuum. Purification by silica gel flash chromatography using 1% ethyl acetate/methylene chloride as eluent provided the title compound as a yellow foam (519 mg, 82%).

As the paragraph descriping shows that 434958-85-7 is playing an increasingly important role.

Reference：
Patent; ABBOTT LABORATORIES; WO2007/76034; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles