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Imidazole as an anti-epileptic: An overview

Imidazole is incorporated into many important biological molecules. The major revolution in the field of imidazole derivatives with antiepileptic properties came with the synthesis of Denzimol and Nafimidone, which leads in its effectiveness among other molecules. The pharmacophore and substitution necessary to elevate the pharmacological effect of these derivatives in curing epilepsy are presented in this review, which can serve the medicinal chemist working on epileptic research to focus on this untouched class of molecules and enlarge its category and synthesize more active and potent anticonvulsant agents.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1224 – PubChem

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In-situ preservation of nitrogen-bearing organics in Noachian Martian carbonates

Understanding the origin of organic material on Mars is a major issue in modern planetary science. Recent robotic exploration of Martian sedimentary rocks and laboratory analyses of Martian meteorites have both reported plausible indigenous organic components. However, little is known about their origin, evolution, and preservation. Here we report that 4-billion-year-old (Ga) carbonates in Martian meteorite, Allan Hills 84001, preserve indigenous nitrogen(N)-bearing organics by developing a new technique for high-spatial resolution in situ N-chemical speciation. The organic materials were synthesized locally and/or delivered meteoritically on Mars during Noachian age. The carbonates, alteration minerals from the Martian near-surface aqueous fluid, trapped and kept the organic materials intact over long geological times. This presence of N-bearing compounds requires abiotic or possibly biotic N-fixation and ammonia storage, suggesting that early Mars had a less oxidizing environment than today.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1117 – PubChem

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Latent Inhibitors. Part 6. Inhibition of Dihydro-orotate Dehydrogenase by Substituted 5-Benzylhydantoins

A series of substituted 5-benzyl-3-(1-carboxy-2-phenylethyl)hydantoins was prepared by condensation of aromatic aldehydes with the corresponding 5-unsubstituted hydantoin followed by reduction of the intermediate benzylidene derivative.The compounds were assessed as inhibitors of dihydro-orotate dehydrogenase from Clostridium oroticum.It was found that hydrophobic and electron-donating substituents in the phenyl ring of the benzyl group favoured binding and irreversible inhibition.The results for the series were correlated with standard substituent parameters from which a mechanism of inhibition was derived.This involved rapid deprotonation of the hydantoin at C-5 followed by rate-determining removal of hydride, or its equivalent.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1068 – PubChem

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2-(2-Fluoro-4-halo-5-substituted phenyl) hydantoins and use

A herbicidal composition which comprises as an active ingredient a compound of the formula: STR1 wherein X is a chlorine atom or a bromine atom, Y is –CH2 –, –S– or –SO2 — and R is a C1 -C4 alkyl group, an allyl group or a propargyl group, and an inert carrier.

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Reference£º
Imidazolidine – Wikipedia,
Imidazolidine | C3H8N709 – PubChem

Extended knowledge of Imidazolidine-2,4-dione

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Reference of 461-72-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.461-72-3, Name is Imidazolidine-2,4-dione, molecular formula is C3H4N2O2. In a Article£¬once mentioned of 461-72-3

Electrochemical characterization of phenytoin and its derivatives on bare gold electrode

Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mumol dm-3) and for a set of higher concentrations (10, 20, 30, 40, 50 mumol dm-3). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e- and 1 proton by irreversible, diffusion controlled process.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1433 – PubChem

Discovery of Imidazolidine-2,4-dione

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Positively charged conjugated microporous polymers with antibiofouling activity for ultrafast and highly selective uranium extraction from seawater

Uranium high-efficiency separation from seawater still has some obstacles such as slow sorption rate, poor selectivity and biofouling. Herein, we report a strategy for ultrafast and highly selective uranium extraction from seawater by positively charged conjugated microporous polymers (CMPs). The polymers are synthesized by Sonogashira-Hagihara cross-coupling reaction of 1,3-dibromo-5,5-dimethylhydantoin and 1,3,5-triethynylbenzene, and then modified with oxime and carboxyl via click reaction. The CMPs show an ultrafast sorption (0.46 mg g?1 day?1) for uranium, and possess an outstanding selectivity with a high sorption capacity ratio of U/V (8.4) in real seawater. The study of adsorption process and mechanism indicate that the CMPs skeleton exhibits high affinity for uranium and can accelerate the sorption, and uranium(VI) is adsorbed on the materials by the interaction of oxime/carboxyl ligands and hydantoin. Moreover, the material can be simply loaded onto the filter membrane, and shows remarkable antibiofouling properties against E. coli and S. aureus and excellent uptake capacity for uranium with low concentration in real seawater. This work may provide a promising approach to design adsorbents with fast adsorption rate, high selectivity and antibacterial activity, and expand the thinking over the development of novel and highly efficient adsorbents for uranium extraction from seawater.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1483 – PubChem

The Absolute Best Science Experiment for Imidazolidine-2,4-dione

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Application of 461-72-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.461-72-3, Name is Imidazolidine-2,4-dione, molecular formula is C3H4N2O2. In a article£¬once mentioned of 461-72-3

Simultaneous CO2 capture and amino acid production using bipolar membrane electrodialysis (BMED)

Amino acid salts have the potential for CO2 capture due to their lower vapor pressure and higher stability against oxidative degradation. In our present study, the CO2 capture and extraction of methionine were simultaneously achieved from methionine salt using bipolar membrane electrodialysis (BMED). CO2 capture was firstly achieved using the methionine salt and then the mixture was converted into methionine and CO2 through the BMED process. Our procedure may significantly challenge the conventional amino acid acidification process using inorganic acids. Results indicated that a high-purity methionine was successfully obtained along with the successful recovery of CO2. The attain methionine extraction ratio can be as high as 99.57% while the energy consumption can be as low as 7.0 kW h for 1 kg of CO2. Therefore, it is a highly effective and environmentally friendly process for capturing CO2 and simultaneous producing this amino acid.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1085 – PubChem

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A review on advances in organoborane-chemistry: Versatile tool in asymmetric synthesis

Background: In the past decades, the hydroboration reaction was serendipitously discovered which occurred by the facile addition of diborane to alkenes and alkynes. Hydroboration reactions produce organoboranes. The organoboranes have marked a new era in the field of organic chemistry because they are versatile chemical intermediates that are readily available to chemists. Objective: The review focuses on recent advancements in organoborane reagents in asymmetric synthesis. We searched the scientific database using relevant keywords such an asymmetric hydroboration, organoboranes etc. The quality research papers were included in the review which discusses the asymmetric synthesis via organoborane compounds. Conclusion: The development of organoborane compounds increased remarkably in few years after hydroboration reaction discovered. Later on, new selective hydroboration agents were developed (for example thexylborane, disiamylborane, dipinylborane, 9-borabicyclenonane, and diisopinocamphylborane which have proven valuable in syntheses of organic compounds with new carbon-carbon bonds. H.C Brown and his co-workers established various procedures to synthesize asymmetric compounds with high enantiomeric excess (ee). There are many different types of strategies in the asymmetric syntheses, but asymmetric syntheses via chiral organoborane reagents have proven to be truly general and have been used to achieve reactions resulting in excellent ee. This review focuses on the advancement.

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Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1099 – PubChem

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Development of a sustainable continuous flow approach toward allantoin

Allantoin is a commodity molecule widely used in cosmetic and pharmaceutical industry for its moisturizing properties. Although allantoin is a naturally occurring compound, its extraction is not economically viable on the industrial scale. Its production relies on urea and glyoxylic acid as starting materials. Current methods need long reaction times and use additives that raise safety and environmental issues. This work presents a novel process toward allantoin that uses Design of Experiments (DoE) and flow chemistry techniques. Intensified continuous flow conditions enable the preparation of high purity allantoin with a productivity of isolated product of 4.65?g?h?1. The research of alternative and more environmental friendly additives for the preparation of allantoin emphasizes that glyoxylic acid itself (in slight excess) is an effective catalyst for the reaction, paving the way to the development of more sustainable synthetic processes. [Figure not available: see fulltext.].

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Reference£º
Imidazolidine – Wikipedia,
Imidazolidine | C3H8N1347 – PubChem