Category: 4769-97-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.,4769-97-5

EXAMPLE 29A 1-methyl-4-nitro-1H-indole A solution of 4-nitroindole (500 mg, 3.1 mmol) in THF (15 mL) at 0 C. was treated portionwise with NaH (290 mg, 9.3 mmol), stirred for 30 minutes, treated dropwise with methyl iodide (0.95 mL, 15.5 mmol), warmed to room temperature for 18 hours, treated sequentially with water and ethyl acetate (200 mL), and washed with brine (100 mL). The organic layer was dried (Na2SO4), filtered, and concentrated to provide the desired product, which was used in the next step without further purification.

As the paragraph descriping shows that 4769-97-5 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US6521658; (2003); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-97-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.

General procedure: In a typical reaction, DAC (0.20 mmol) was mixed with indole (0.20 mmol) and PTSA (10 molpercent) in ethanol (1.0 mL). The mixture was then stirred at 60¡ãC for 20 min. After reaction, the mixture was cooled to room temperature, and the product was obtained by isolation with preparative TLC (eluting solution: petroleum ether/ethyl acetate=5/1 (v/v)). Tests for substrate scope were all performed with an analogous procedure. Large scale synthesis was also performed in a similar procedure. The product was isolated by silica column chromatography (eluting solution: petroleum ether/ethyl acetate=8/1 (v/v)).

4769-97-5 4-Nitroindole 145766, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Changhui; Zhou, Li; Huang, Wenbo; Wang, Man; Gu, Yanlong; Tetrahedron; vol. 72; 4; (2016); p. 563 – 570;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.,4769-97-5

General procedure: Sodium hydride (1.2 g, 50 mmol) was added portionwise to a solution of 4-nitroindole 1 (8.2 g, 50 mmol) in abs. DMF (50 mL) cooled in an ice bath. Methyl iodide (3.27 mL, 55 mmol) or corresponding alkyl bromide (55 mmol) was added dropwise and the reaction stirred for 4 h at room temperature with TLC analysis monitoring for the completion of the reaction. The solvent was removed under vacuum and the residue partitioned between ethyl acetate and water. The organic phase was dried over magnesium sulfate and the solvent evaporated to give residue. 1-Methyl-4-nitro-1H-indole (2). Yellow solid, mp 112-113, yield 95%. 1H NMR (300 MHz, DMSO-d6) delta 8.09 (d, 1H, J = 8.7 Hz, H-5), 7.99 (d, 1H, J = 8.7 Hz, H-7), 7.76 (d, 1H, J = 3.0 Hz, H-2), 7.36 (t, 1H, J = 8.1 Hz, H-6), 7.03 (d, 1H, J = 3.0 Hz, H-3), 3.93 (s, 3H, CH3-1). Calcd. for C9H8N2O2: C, 61.36; H, 4.58; N, 15.90; Found: C, 61.50; H, 4.30; N, 15.70%.

The synthetic route of 4769-97-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Halaiev, Olexandr; Garazd, Myroslav; Gzella, Andrzej; Lesyk, Roman; Tetrahedron Letters; vol. 58; 13; (2017); p. 1324 – 1325;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-97-5, 4-Nitroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 4-Aminoindole. Iron powder (1.20 g, 21.58 mmol) and acetic acid (2.47 mL, 43.19 mmol) are added to a solution of 4-nitroindole (1.0 g, 6.17 mmol) in ethanol (20 mL). The resulting suspension is heated to reflux for 14 hours. The ethanol is removed by rotary evaporation and the residue is partitioned between water and ethyl acetate. The ethyl acetate layer is dried over magnesium sulfate, filtered, and the solvents removed by rotary evaporation. The crude residue is purified via silica gel column chromatography using 1% methanol/methylene chloride as the eluent. The appropriate fractions are combined and the solvents removed by rotary evaporation to yield 0.815 g of 4-aminoindole as an orange solid (82% yield).

4769-97-5, 4769-97-5 4-Nitroindole 145766, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; The Procter & Gamble Company; US6162818; (2000); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.

A mixture of 4-nitroindole (15 grams, 92.5 mmol), iron powder (25.92 grams, 462.9 mmol), concentrated hydrochloric acid (5 mL) and water (50 mL) in ethanol (150 mL) was refluxed at 90 0C and the progress of the reaction was monitored by thin layer chromatography. After completion of the reaction (2 hours), the reaction mixture was filtered through hy-flow bed and the filtrate was concentrated under reduced pressure. The residual mass was diluted with ice water (500 mL), basified with aqueous sodium hydroxide solution to pH 9 – 10 and extracted with ethyl acetate (2.x 250 mL). The combined organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product (13.2 grams), thus obtained, was purified by column chromatography using silica-gel (100 – 200 mesh), the eluent system being ethyl acetate and n-hexane (1:9) to obtain 12.13 grams of title product. Melting Range: 101.7 – 106.8 0C; I.R (cm-‘): 1109, 1519, 2931, 3325, 3394, 3440;1H-NMR (ppm): 3.92 (2H, bs), 6.40 – 6.42 (IH, m), 6.46 – 6.47 (IH, m), 6.86 – 6.88 (IH; d, J = 8.14 Hz), 6.99 – 7.03 (IH, t, J = 7.8 Hz), 7.11 – 7.12 (IH, t, 2.8 Hz), 8.11 (IH, bs); Mass (m/z): 133.15 (M+H) +

4769-97-5, As the paragraph descriping shows that 4769-97-5 is playing an increasingly important role.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; WO2009/34581; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles