Category: 4771-48-6

Somei, Masanori; Yamada, Fumio; Naka, Katsumi published the artcile< The chemistry of indoles. XL. Tin-thall reaction, a versatile method for cross-coupling tin compounds with thallium compounds>, Computed Properties of 4771-48-6, the main research area is alkylindolecarboxaldehyde; indolylthallium fluoroacetate coupling organotin; coupling indolylthallium fluoroacetate catalyst.

Indolylthallium compound I was treated with organotin compounds and Pd acetate catalyst to yield 4-substituted indoles II (R1 = alkyl, Ph, pyridyl).

Chemical & Pharmaceutical Bulletin published new progress about Coupling reaction catalysts. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Computed Properties of 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lu, Lin; Luo, Chenguang; Peng, Hui; Jiang, Huanfeng; Lei, Ming; Yin, Biaolin published the artcile< Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO3>, Application In Synthesis of 4771-48-6, the main research area is sulfonyl indoline iron catalyst UV cyclization indolylmethylpropiolamide sodium sulfite.

A variety of structurally novel polycyclic sulfonyl indolines were synthesized via FeCl2-catalyzed or UV-driven intramol. formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methylpropiolamides with NaHSO3 in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step.

Organic Letters published new progress about Crystal structure. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application In Synthesis of 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Marcin, Lawrence R.; Denhart, Derek J.; Mattson, Ronald J. published the artcile< Catalytic Asymmetric Diazoacetate Cyclopropanation of 1-Tosyl-3-vinylindoles. A Route to Conformationally Restricted Homotryptamines>, Application In Synthesis of 4771-48-6, the main research area is homotryptamine preparation vinylindole diazoacetate asym cyclopropanation.

Substituted 1-tosyl-3-vinylindoles undergo catalytic asym. cyclopropanation with Et and tert-Bu diazoacetate to afford N-protected trans-2-(indol-3-yl)-1-cyclopropanecarboxylic esters in good yield and high enantiomeric excess (81-88% ee). The resulting cycloadducts are demonstrated to be useful intermediates for the synthesis of conformationally restricted, homotryptamine-like analogs such as BMS-505130 (I.maleate).

Organic Letters published new progress about Cyclopropanation catalysts, stereoselective. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application In Synthesis of 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kim, Weonjeong; Koo, Jangwoo; Lee, Hong Geun published the artcile< Benzylic C(sp3)-C(sp2) cross-coupling of indoles enabled by oxidative radical generation and nickel catalysis>, Safety of 4-Methyl-1H-indole-3-carbaldehyde, the main research area is benzylic indole preparation; indole aryl halide arylation cross coupling photocatalyst; acyl indole preparation; acid anhydride indole acylation cross coupling photocatalyst.

A mechanistically unique functionalization strategy for a benzylic C(sp3)-H bond was developed based on facile oxidation event of indole substrates. This novel pathway was initiated by efficient radical generation at benzylic position of substrate, with subsequent transition metal catalysis to complete overall transformation. Ultimately, an aryl or an acyl group could be effectively delivered from an aryl (pseudo)halide or an acid anhydride coupling partner, resp. The developed method utilized mild conditions and exhibited a wide substrate scope for both substituted indoles and C(sp2)-based reaction counterparts. Mechanistic studies showed that competitive hydrogen atom transfer (HAT) processes, which were frequently encountered in conventional methods, are not involved in the product formation process of the developed strategy.

Chemical Science published new progress about Acylation catalysts (photochem.). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Safety of 4-Methyl-1H-indole-3-carbaldehyde.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cheng, Guangsheng; Deng, Hongmei; He, Xiang; Gao, Yu; Li, Chunju; Jia, Xueshun; Li, Jian published the artcile< Isocyanide-Based Multicomponent Reaction To Furnish N-Functionalized Indoles by using N-Acyliminium Ions as Key Intermediates>, Product Details of C10H9NO, the main research area is indolyl pyrrolidinone preparation.

The present work discloses an efficient multicomponent reaction of isocyanides, allenoates, and indoles. This protocol provides rapid and direct access to N-functionalized indoles from readily available starting materials, in the absence of any catalyst. The strategy also features a broad substrate scope and mild conditions.

European Journal of Organic Chemistry published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Product Details of C10H9NO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heath-Brown, B.; Philpott, P. G. published the artcile< The indole series. I. Indolylalkylamines>, Computed Properties of 4771-48-6, the main research area is .

The preparation of a large series of indolylalkylamines is described, including α-alkyl-, α,α-dialkyl-, and N-alkyltryptamines. New methods include a modification of the Abramovich synthesis giving α,N-dimethyltryptamines directly.

Journal of the Chemical Society published new progress about 4771-48-6. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Computed Properties of 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hopkins, Megan D.; Abebe, Felagot A.; Scott, Kristina A.; Ozmer, Garett L.; Sheir, Alec A.; Schroeder, Lucas J.; Sheaff, Robert J.; Lamar, Angus A. published the artcile< Synthesis and identification of heteroaromatic N-benzyl sulfonamides as potential anticancer agents>, SDS of cas: 4771-48-6, the main research area is heteroaromatic Nbenzyl sulfonamide preparation anticancer.

A new approach for regioselective incorporation of a sulfonamide unit to heteroarene scaffolds has been developed and is reported within. As a result, a variety of primary benzylic N-alkylsulfonamides have been prepared via a two-step (one pot) formation from the in situ reduction of an intermediate N-sulfonyl imine under mild, practical conditions. The compounds have been screened against a variety of cell lines for cytotoxicity effects using a Cell Titer Blue assay. The cell viability investigation identifies a subset of N-benzylic sulfonamides derived from the indole scaffold to be targeted for further development into novel mols. with potential therapeutic value. The most cytotoxic of the compounds prepared, I (R1 = Me, R2,R3 = H; R4 = 4-ClC6H4), exhibited higher potency than other well-known anticancer agents Indisulam and ABT-751.

Organic & Biomolecular Chemistry published new progress about Antitumor agents. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, SDS of cas: 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lin, Hui-Shan; Chen, Shu-Jun; Huang, Jing-Mei published the artcile< Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N-O cleavage>, Category: indole-building-block, the main research area is indolylemthyliminooxy acid electrochem oxidative decarboxylation cleavage; indolyl carbonitrile preparation.

A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals was developed through the electrochem. oxidative decarboxylation of α-imino-oxy acids. This protocol provides an efficient approach to nitriles with a broad range of functional-group tolerance under ambient conditions and can be applied for one-pot gram-scale synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Category: indole-building-block.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Duan, Shengguo; An, Yuehui; Xue, Bing; Chen, Yidian; Zhang, Wan; Xu, Ze-Feng; Li, Chuan-Ying published the artcile< Synthesis of Pyrido[2,3-b]indole Derivatives via Rhodium-Catalyzed Cyclization of Indoles and 1-Sulfonyl-1,2,3-triazoles>, Application of C10H9NO, the main research area is indole sulfonyltriazole preparation rhodium catalyst diastereoselective cycloaddition; pyridoindole preparation.

Acyloxy-substituted α,β-unsaturated imines generated in-situ from triazoles acts as aza-[4C] synthons and be trapped by indoles in a stepwise [4 + 2] cycloaddition reaction, thus providing rapid access to valuable pyrido[2,3-b]indoles in high yields. Attractive features of this reaction system included operational simplicity, readily available substrates, construction of sterically demanding quaternary centers and convenient derivatization using triflate.

Advanced Synthesis & Catalysis published new progress about [4+2] Cycloaddition reaction (stereoselective). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application of C10H9NO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Qian, Chenxiao; Liu, Meiwen; Sun, Jianwei; Li, Pengfei published the artcile< Chiral phosphoric acid-catalyzed regio- and enantioselective reactions of functionalized propargylic alcohols>, Synthetic Route of 4771-48-6, the main research area is spiro isoindoline pyrroloindolone preparation regioselective enantioselective.

Here, the scope of propargylic alcs. and the power of CPA catalysis was expanded. With the established system, racemic 3-alkynyl-3-hydroxyisoindolinones reacted efficiently to form diverse spirocyclic heterocycles I [R1 = Ph, 4-BrC6H4, 2-thienyl, etc.; R2 = Me, Ph; R3 = H, 5-Me, 6-F, etc.] with high enantioselectivity. Regiodivergence was also observed with different indole nucleophiles. Importantly, the key covalently bonded CPA adduct was isolated, characterized and further confirmed to be chem. competent, and a possible covalent activation mode was proposed accordingly.

Organic Chemistry Frontiers published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Synthetic Route of 4771-48-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles