With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-58-9,Ethyl5-methoxyindole-2-carboxylate,as a common compound, the synthetic route is as follows.
i Ethyl 5-hydroxyindole-2-carboxylate Boron tribromide (64.58 g) was added dropwise to a stirred solution of ethyl 5-methoxyindole-2-carboxylate (20 g) in dichloromethane (1000 ml) at -78¡ã C. under an atmosphere of argon. The reaction was allowed to warm to room temperature and stirred for a further 2 hours. The reaction was poured into ice/saturated aqueous sodium hydrogen carbonate solution with stirring and extracted with ethyl acetate. Combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate solution, water, aqueous saturated sodium chloride solution and dried. The solution was concentrated in vacuo and the residue was purified by column chromatography using 0-60percent diethyl ether: iso-hexane as eluent to yield product as a white solid (9.02 g, 48percent). NMR(CD3SOCD3): delta 1.31 (t, 3H), 4.29 (q, 2H), 6.79 (dd, 1H), 6.90 (dd, 1H), 7.22 (d, 1H), 8.84 (s, 1H), 11.52 (brs, 1H); m/z 206 (MH+)., 4792-58-9
The synthetic route of 4792-58-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Faull, Alan Wellington; Kettle, Jason Grant; US2003/144339; (2003); A1;,
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