Category: 4792-67-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-67-0,Ethyl 5-chloro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

[Referential Example 280] ethyl 3-bromo-5-chloroindole-2-carboxylate: N-Bromosuccinimide (440 mg) was added to a solution of ethyl 5-chloroindole-2-carboxylate (500 mg) in N,N-dimethylformamide (10 ml).. The reaction mixture was stirred at room temperature for 18 hours, and the solvent was distilled off under reduced pressure.. The residue was partitioned in ethyl acetate and water, and a water layer was extracted with ethyl acetate.. The resultant organic layers were combined, washed with saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate.. The solvent was distilled off, the residue was purified by column chromatagraphy on silica gel (ethyl acetate:hexane = 1:9), and white powder thus obtained was washed with hexane to obtain the title compound (680 mg).1H-NMR (CDCl3) delta: 1.42-1.48(3H,m), 4.43-4.49(2H,m), 7.30-7.32(2H,m), 7.65(1H,d,J=0.74Hz), 9.11(1H,s) MS (FAB) m/z: 303(M+H)+.

4792-67-0, The synthetic route of 4792-67-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1405852; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-67-0,Ethyl 5-chloro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

METHOD AD[00234| To a flask was added under argon indole 10 (leq) was added Iodine (1.98 eq.), solid potassium hydroxyde (1 eq.) and anhydrous DMF (4.5mL/mmol). The reaction mixture was stirred 3 hours then water was added and the slurry filtered through paper filter, the solid was dried under reduced pressure and triturated/filtered in water several times to yield after dryed under reduced pressure the 3-iodoindole 61., 4792-67-0

The synthetic route of 4792-67-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IDENIX PHARMACEUTICALS, INC.; WO2008/42240; (2008); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles