Category: 4792-71-6

4792-71-6, 5,7-Dichloro-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A vial was charged with 5,7-dichloro-lH-indole-2-carboxylic acid (230 mg, 1.00 mmol, 1.00 equiv), DCM (10 mL), and oxalyl chloride (381 mg, 3.00 mmol, 3.00 equiv). N,N- Dimethylformamide (0.05 mL) was added at 0 C, as described in Example 16, Step 3. The resulting solution was stirred for 4 hours at room temperature and concentrated under reduced pressure to provide 248 mg (crude) of 5,7-dichloro-lH-indole-2-carbonyl chloride as a yellow solid., 4792-71-6

4792-71-6 5,7-Dichloro-1H-indole-2-carboxylic acid 4983238, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4792-71-6, 5,7-Dichloro-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 102 R-Methyl 2-[(5-7-dichloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionate From 5,7-dichloro-1H-indole-2-carboxylic acid and D-phenylalanine methyl ester. 1H NMR (300 MHz, CDCl3) delta 3.25 (m, 2H), 3.80/3.95 (s, 3H), 5.10 (m, 1H), 6.62 (d, 6 Hz, 1H), 6.69 (d, 2 Hz, 1H), 7.10 – 7.15 (m, 2H), 7.25 – 7.35 (m, 3H), 7.50 – 7.56 (s, 1H), 9.35 (br, 1H)., 4792-71-6

The synthetic route of 4792-71-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; PFIZER INC.; EP1134213; (2001); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4792-71-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-71-6,5,7-Dichloro-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 102 R-Methyl 2-[(5-7-dichloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionate From 5,7-dichloro-1H-indole-2-carboxylic acid and D-phenylalanine methyl ester. 1 H NMR (300 MHz, CDCl3) delta 3.25 (m, 2H), 3.80/3.95 (s, 3H), 5.10 (m, 1H), 6.62 (d, 6 Hz, 1H), 6.69 (d, 2 Hz, 1H), 7.10-7.15 (m, 2H), 7.25-7.35 (m, 3H), 7.50-7.56 (s, 1H), 9.35 (br, 1H).

As the paragraph descriping shows that 4792-71-6 is playing an increasingly important role.

Reference：
Patent; Pfizer, Inc.; US6107329; (2000); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles