Category: 501-98-4

501-98-4, Name is Trans-4-Hydroxycinnamic Acid, molecular formula is C9H8O3, belongs to indole-building-block compound, is a common compound. In a patnet, author is Sailaja, E., once mentioned the new application about 501-98-4, Computed Properties of https://www.ambeed.com/products/501-98-4.html.

In view of known antitumor and cytotoxic properties of 2- and 3-pyridinyl substituted indole derivatives, respectively a number of isomeric N-pyridinyl substituted indoles and their analogs were synthesized as potential cytotoxic agents. A greener approach was developed to synthesize these compounds via an ultrasound assisted selective N – 1 heteroarylation of indoles. The methodology involved reaction of indoles with heteroaryl halides in PEG-400 under ultrasound irradiation. One of the products i.e. 1-(pyrimidin-2-yl)-1H-indole was further functionalized via Pd-mediated CAH activation at C-2 on the indole ring. All the synthesized N – 1 heteroarylindoles were tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Some of the compounds showed promising and selective cytotoxic effects toward leukemia cells. (C) 2015 King Saud University. Published by Elsevier B.V.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.501-98-4, Name is Trans-4-Hydroxycinnamic Acid, SMILES is O=C(O)/C=C/C1=CC=C(O)C=C1, belongs to indole-building-block compound. In a document, author is Bonandi, Elisa, introduce the new discover, Category: indole-building-block.

The aza-alkylation reaction at indole’s C3 position allows the introduction of a differently substituted aminomethyl group, with the formation of a new stereogenic centre. The reaction involves essentially three different partners: an indole, aldehyde and amine. The formation of the reactive iminium species can be catalyzed by metals, Bronsted acids, Lewis acids or organocatalysts. The stereoselective reaction is feasible with satisfactory outcomes. This review summarizes the recent (2000-2019) meaningful papers in which the in-depth study and exploitation of this reactivity are reported.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 501-98-4 is helpful to your research. Category: indole-building-block.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of Trans-4-Hydroxycinnamic Acid, 501-98-4, Name is Trans-4-Hydroxycinnamic Acid, molecular formula is C9H8O3, belongs to indole-building-block compound. In a document, author is Gao, Run-Duo, introduce the new discover.

An intermolecular Pd-catalyzed allylic dearomatization reaction of polycyclic indoles with substituted allylic carbonates was realized in the presence of a newly synthesized chiral phosphoramidite ligand. Various polycyclic indoline and indolenine derivatives were successfully synthesized in excellent yields (up to 99%) with excellent enantioselectivity (up to 98% ee). The obtained products could undergo versatile transformations, increasing the application potential of the method in organic synthesis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 501-98-4. Quality Control of Trans-4-Hydroxycinnamic Acid.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles