Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.51-45-6, Name is Histamine, SMILES is NCCC1=CNC=N1, belongs to indole-building-block compound. In a document, author is Xie, Chao-Chao, introduce the new discover, Quality Control of Histamine.
An organocatalysis triggered highly regio- and stereoselective two-step sequence between hemiacetals and indole-containing nitroolefins was developed. The key to the success of this sequence was the intramolecular oxocarbenium ion induced collective alkylation at the C3, C2, or N1-position of the indole moiety, respectively, providing biologically important polycyclic indole derivatives with different ring connectivities. An unexpected epimerization was observed during the C3-alkylation process, which generated products with different relative configurations compared with the C2- and N1-alkylation products.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 51-45-6 is helpful to your research. Quality Control of Histamine.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles