51310-54-4, 2-(Trifluoromethyl)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 18 Preparation of 5-Nitro-2-(trifluoromethyl)indole STR35 A solution of 2-(trifluoromethyl)indole (0.2 g, 1.1 mmole) in acetic anhydride is treated with (0.131 g, 0.54 mmole of) Cu(NO3)2.3H2 O at 0 C., stirred for 2.5 hours at room temperature and diluted with water and ether. The phases are separated; the organic phase is washed sequentially with saturated NaHCO3 and brine, dried over MgSO4 and concentrated in vacuo to give a yellow solid residue. The residue is chromatographed (silica gel/20% ethyl acetate in hexanes) to give the title product as a yellow solid, 0.073 g (29.4% yield), mp 190-193 C., identified by IR, 1 H-NMR, 19 FNMR and mass spectral analyses.
The synthetic route of 51310-54-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; American Cyanamid Company; US5502071; (1996); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles