Facile One-Pot Access to 伪-Diazo-尾-ketosulfones from Sulfonyl Chlorides and 伪-Haloketones was written by Dar’in, Dmitry;Kantin, Grigory;Bakulina, Olga;Krasavin, Mikhail. And the article was included in Synthesis in 2020.COA of Formula: C10H8ClNO3S This article mentions the following:
A convenient one-pot approach to the preparation of 伪-diazo-尾-ketosulfones R1SO2C(=N2)C(O)R2 [R1 = Me, cyclohexyl, Ph, etc.; R2 = Me, Ph, 4-FC6H4, etc.] from sulfonyl chlorides was described. It involved the conversion of sulfonyl chloride to sodium sulfinate, alkylation of latter with 伪-haloketones followed by diazo transfer using ‘sulfonyl-azide-free’ (SAFE) protocol in aqueous medium. The simple and expedient method relied on readily available starting materials and provided facile access to a wide variety of valuable diazo reagents for organic synthesis. In the experiment, the researchers used many compounds, for example, 1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0COA of Formula: C10H8ClNO3S).
1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C10H8ClNO3S
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles