Category: 52488-36-5

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 52488-36-5, Name is 4-Bromo-1H-indole, SMILES is C1=C[NH]C2=C1C(=CC=C2)Br, belongs to indole-building-block compound. In a document, author is Safe, Stephen, introduce the new discover, Product Details of 52488-36-5.

The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli, and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) play an important role in maintaining cellular homeostasis and in pathophysiology. In blood-derived tumors (leukemias and lymphomas), NR4A expression is low and NR4A1(-/-) /NR4A3(-/-) double knockout mice rapidly develop acute myelocytic leukemia, suggesting that these receptors exhibit tumor suppressor activity. Treatment of leukemia and most lymphoma cells with drugs that induce expression of NR4A1 and NR4A3 enhances apoptosis, and this represents a potential dinical application for treating this disease. In contrast, most solid tumor-derived cell lines express high levels of NR4A1 and NR4A2, and both receptors exhibit pro-oncogenic activities in solid tumors, whereas NR4A3 exhibits tumor-specific activities. Initial studies with retinoids and apoptosis-inducing agents demonstrated that their cytotoxic activity is NR4A1 dependent and involved drug-induced nuclear export of NR4A1 and formation of a mitochondria] proapoptotic NR4A1-bcl-2 complex. Drug-induced nuclear export of NR4A1 has been reported for many agents/ biologics and involves interactions with multiple mitochondrial and extramitochondrial factors to induce apoptosis. Synthetic ligands for NR4A1, NR4A2, and NR4A3 have been identified, and among these compounds, bis-indole derived (CD1M) NR4A1 ligands primarily act on nuclear NR4A1 to inhibit NR4A1-regulated pro-oncogenic pathways/genes and similar results have been observed for CDIMs that bind NR4A2. Based on results of laboratory animal studies development of NR4A inducers (blood-derived cancers) and NR4A1/NR4A2 antagonists (solid tumors) may be promising for cancer therapy and also for enhancing immune surveillance.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 52488-36-5 is helpful to your research. Product Details of 52488-36-5.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 52488-36-5, Name is 4-Bromo-1H-indole, SMILES is C1=C[NH]C2=C1C(=CC=C2)Br, in an article , author is Pagano, Angela, once mentioned of 52488-36-5, Recommanded Product: 4-Bromo-1H-indole.

A series of atropisomeric molecules containing the indole ring and two stereogenic axes were prepared. The four atropisomers were resolved by enantioselective HPLC. The rotational barriers of the indole-naphthyl axes were evaluated by means of kinetic analysis either by NMR or enantioselective HPLC. The absolute configuration of the atropisomers was determined by a combination of X-ray spectroscopy and TD-DFT simulation of electronic circular dichroism spectra.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 52488-36-5, you can contact me at any time and look forward to more communication. Recommanded Product: 4-Bromo-1H-indole.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Related Products of 52488-36-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 52488-36-5, Name is 4-Bromo-1H-indole, SMILES is C1=C[NH]C2=C1C(=CC=C2)Br, belongs to indole-building-block compound. In a article, author is Irgashev, Roman A., introduce new discover of the category.

During this study, series of benzo[4,5]thieno[3,2-b]indoles, pyrido[3′,2′:4,5]thieno[3,2-b]indoles and pyrazino[2′,3′:4,5]thieno[3,2-b]indoles were efficiently synthesized from benzo- and pyrido- or pyrazino-fused 3-aminothiophene-2-carboxylates, respectively, using one-pot two-step strategy based on the Fischer indolization reaction. The essence of this synthetic approach is acid-promoted reaction of the 3-aminothiophene intermediates, in situ generated from the corresponding ring-fused 3-aminothiophene-2-carboxylates, with arylhydrazines to give arylhydrazones of thiophen-3(2H)-ones, followed by their indolization to afford thieno[3,2-b]indole-cored molecules. (C) 2020 Elsevier Ltd. All rights reserved.

Related Products of 52488-36-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 52488-36-5 is helpful to your research.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In an article, author is Bresnahan, Caitlin G., once mentioned the application of 52488-36-5, Name is 4-Bromo-1H-indole, molecular formula is C8H6BrN, molecular weight is 196.04, MDL number is MFCD00671502, category is indole-building-block. Now introduce a scientific discovery about this category, Computed Properties of C8H6BrN.

Mechanistic Perspectives in the Regioselective Indole Addition to Unsymmetrical Silyloxyallyl Cations

Our investigations on the reaction mechanism to account for regioselectivity on the addition of indoles to unsymmetrical silyloxyallyl cations are reported. Using both experimental and computational methods, we confirmed the significance of steric effects from the silyl ether group toward directing the inward approach of indoles, leading to nucleophilic attack at the less substituted electrophilic alpha’-carbon. The role of residual water toward accelerating the rate of reaction is established through stabilization of the participating silyloxyallyl cation.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 52488-36-5, Computed Properties of C8H6BrN.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52488-36-5, 4-Bromo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52488-36-5

To a solution of 4-bromo-1H-indole (LXX) (10 g, 50.8 mmol, 1 eq), DMAP (622 mg, 5.1 mmol, 0.1 eq) and TEA (10.6 ml, 76.1 mmol, 3 eq) in DCM (200 mL) was added Boc2O (14.4 mL, 61 mmol, 1.2 eq) at 0C. The reaction was warmed to room temperature and stirred for 2 h. Water (200 mL) was added and the mixture was extracted with DCM twice. The solvent was evaporated under vacuum to give tert-butyl 4-bromo-1H-indole-1-carboxylate (LXXI) as white solid (11.4 g, 38.5 mmol, 76% yield). 1H NMR (CDCI3, 400 MHz) delta ppm 1.68 (s, 9H), 6.64 (d, J=4Hz, 1H), 7.17 (t, J=8.4Hz, 1H), 7.39 (d, J=7.6Hz, 1H), 7.64 (d, J=3.2Hz, 1H), 8.11 (d, J=8.0Hz, 1H); ESIMS found for C13H14BrNO2 m/z 297.1 (M+H).

52488-36-5 4-Bromo-1H-indole 676494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; SAMUMED, LLC.; KC, Sunil, Kumar; WALLACE, David, Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (279 pag.)WO2017/23973; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.

Under a nitrogen atmosphere, cuprous iodide (3.0 mol%, 0.7 mg), sodium iodide (1.0 equiv., 18.7 mg) and magnets were added to a previously baked 10 mL glass pressure tube. Dioxane (0.2 mL), 4-bromoindole (0.125 mmol, 1.0 equiv., 24.5 mg) and N,N’-dimethylethylenediamine (10.0 mol%, 1.1 mg) were then added. After the addition, the glass pressure tube was placed in a metal module that had been preheated to 100 C. and stirred for 10 hours. Cooled to room temperature, cuprous oxide was added under a nitrogen atmosphere (20mol%, 3.6mg), nine carbonyl iron (3mol%, 1.4mg), N- methylpyrrolidinone (0.5mL) and phenyl silane (3.0equiv., 40.6 Mg). The tube was purged of air and charged with carbon dioxide (5.0 equiv., 15 mL) and ammonia gas (5.0 equiv., 15 mL). After the addition was completed, the reactor was placed in a metal module preheated to 160C and stirred for 10 hours. After the reaction was completed, the reaction system was cooled to room temperature and pressure was slowly released. Use of dodecane as an internal standard through gas chromatography The working curve determines that the yield is 84%., 52488-36-5

52488-36-5 4-Bromo-1H-indole 676494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Li Yuehui; Wang Hua; Dong Yanan; Ke Lisitian¡¤shanduofu; (20 pag.)CN108017557; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.

52488-36-5, General procedure: Phosphorus oxychloride (2.3 mL, 24.0 mmol) was added to ice-cold, stirred, dry dimethylformamide (7.8 mL, 99.0 mmol) followed by dry pyridine (2.0 mL, 26.0 mmol). A solution of the foregoing protected indole-4-methanol 33 (8.50 g, 22.0 mmol) in dimethylformamide (3 mL) was then added dropwise and the resulting solution warmed to 35 C for 0.75 h before being poured onto ice. Sodium hydroxide (4.00 g) in water (200 mL) was added in portions and the resulting mixture boiled for 2 min then cooled and extracted with dichloromethane (3¡Á50 mL). The combined extracts were dried, filtered and evaporated to give the indole-3-carboxaldehyde35 (7.52 g, 82%) as a brown oil

As the paragraph descriping shows that 52488-36-5 is playing an increasingly important role.

Reference£º
Article; Griffiths-Jones, Charlotte M.; Knight, David W.; Tetrahedron; vol. 67; 44; (2011); p. 8515 – 8528;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.,52488-36-5

[00653] To a solution of 4-bromo-1H-indole (2.0 g, 0.01 mol) in DMF (30 mL) was added NaH (0.6 g, 0.015 mol) at 0 C. The resultant solution was stirred at rt for 30 min, then Mel (1.42 g, 0.01 mol) was added and stirred at for 3 h. The reaction mixture was poured into ice-water and extracted with EtOAc, the organic phase was dried over Na2S04, filtered and concentrated, the crude was purified by SGC to obtain 4-bromo-1-methyl-1H-indole (1.05 g, 50%) as a yellow solid.

As the paragraph descriping shows that 52488-36-5 is playing an increasingly important role.

Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles