Category: 52537-00-5

On May 26, 2020, Jia, Wei-Guo; Gao, Li-Li; Wang, Zhi-Bao; Wang, Jing-Jing; Sheng, En-Hong; Han, Ying-Feng published an article.Formula: C8H8ClN The title of the article was NHC-Palladium(II) Mononuclear and Binuclear Complexes Containing Phenylene-Bridged Bis(thione) Ligands: Synthesis, Characterization, and Catalytic Activities. And the article contained the following:

Mono- and binuclear Pd(II) complexes with N-heterocyclic carbene (NHC) and phenylene-bridged bis(thione) (SCS) ligands were prepared and characterized by 1H and 13C NMR spectroscopy, IR, and mass spectrometry. The mol. structures of 1b, 2a, and 3b were determined by the single-crystal x-ray diffraction method. The catalytic activities of the synthesized Pd complexes in the regioselective reduction of quinolines to the corresponding 1,2,3,4-tetrahydroquinolines were thoroughly studied with NH3-borane under mild reaction conditions. The activities of the binuclear Pd(NHC) complexes were higher than those of the corresponding mononuclear complexes under the same conditions. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Formula: C8H8ClN

The Article related to imidazolylidene palladium phenylene bridged dithione complex preparation reduction catalyst, crystal structure imidazolylidene palladium phenylene bridged dithione complex, mol structure imidazolylidene palladium phenylene bridged dithione complex and other aspects.Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 19, 1996, Arnold, Lee D.; Moyer, Mikel P.; Sobolov-jaynes, Susan B. published a patent.COA of Formula: C8H8ClN The title of the patent was Preparation of heterocyclic ring-fused pyrimidines for treatment of hyperproliferative diseases. And the patent contained the following:

The title compounds [I; Y = (un)substituted unsaturated or aromatic 5- or 6-membered ring (together with the carbons to which it is attached) containing one to three heteroatoms such as S, O, N (at least one of said heteroatoms is N); Z = NR1R2 (wherein R1 = H; R2 = (un)substituted Ph, heterocycle)], useful in the treatment of hyperproliferative diseases, such as cancers, and psoriasis or benign prostatic hyperplasia, were prepared Thus, reaction of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine with 3-aminophenylacetylene in pyridine afforded 12% II.HCl. In general, compounds I were effective at 0.2-2.5 g/day for an average 70 kg human. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to pyrimidine heterocyclyl fused preparation hyperproliferative disease, antitumor agent heterocyclopyrimidine fused preparation, psoriasis heterocyclopyrimidine fused preparation, benign prostatic hyperplasia heterocyclopyrimidine fused preparation and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 26, 2018, Wang, Qingfu; Chai, Huining; Yu, Zhengkun published an article.Computed Properties of 52537-00-5 The title of the article was Acceptorless Dehydrogenation of N-Heterocycles and Secondary Alcohols by Ru(II)-NNC Complexes Bearing a Pyrazoyl-indolyl-pyridine Ligand. And the article contained the following:

Ru(II) hydride complexes bearing a pyrazolyl-(2-indol-1-yl)-pyridine ligand were synthesized and structurally characterized by NMR anal. and x-ray single crystal crystallog. determinations These complexes efficiently catalyzed acceptorless dehydrogenation of N-heterocycles and secondary alcs., resp., exhibiting highly catalytic activity with a broad substrate scope. The present work established a strategy to construct highly active transition-metal complex catalysts, and provides an atom-economical and environmentally benign protocol for the synthesis of aromatic N-heterocyclic compounds and ketones. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Computed Properties of 52537-00-5

The Article related to ruthenium pyrazolylindolylpyridine hydride pincer complex preparation catalyst dehydrogenation indoline, crystal structure pyrazolylindolylpyridine ruthenium hydride pincer complex, mol structure pyrazolylindolylpyridine ruthenium hydride pincer complex, pyrazolylindolylpyridine pincer ligand preparation cyclometalation ruthenium chloride and other aspects.Computed Properties of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Tingting; Wu, Kaikai; Wang, Liandi; Yu, Zhengkun published an article in 2019, the title of the article was Potassium tert-butoxide-promoted acceptorless dehydrogenation of N-heterocycles.Category: indole-building-block And the article contains the following content:

Potassium tert-butoxide-promoted acceptorless dehydrogenation of N-heterocycles was efficiently realized for the generation of N-heteroarenes such as quinolines, quinoxalines, indoles, quinazolinones and isoquinolines and hydrogen gas under transition-metal-free conditions. In the presence of KOtBu base, a variety of six- and five-membered N-heterocyclic compounds efficiently underwent acceptorless dehydrogenation to afford the corresponding N-heteroarenes and H2 gas in o-xylene at 140 °C. The present protocol provided a convenient route to aromatic nitrogen-containing compounds and H2 gas. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Category: indole-building-block

The Article related to quinoline quinoxaline indole quinazolinone isoquinoline preparation, tetrahydroquinoline dehydrogenation potassium tert butoxide promoted, tetrahydroquinoxaline dehydrogenation potassium tert butoxide promoted, indoline dehydrogenation potassium tert butoxide promoted, quinazoline dehydrogenation potassium tert butoxide promoted and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 4, 2021, Luo, Zaoli; Liu, Yungen; Tong, Ka-Chung; Chang, Xiao-Yong; To, Wai-Pong; Che, Chi-Ming published an article.Reference of 6-Chloro-2,3-dihydro-1H-indole The title of the article was Luminescent Platinum(II) Complexes with Bidentate Diacetylide Ligands: Structures, Photophysical Properties and Application Studies. And the article contained the following:

A series of platinum(II) m-terphenyl 2,2”-diacetylide complexes supported by diimines (2,2′-bipyridines, 1,10-phenanthroline, 2,2′-bipyrimidine) or bis-N-heterocyclic carbenes 3-RIm(CH2)nImR-3′ (R = Bu, Me; n = 1-3) ligands have been prepared The diacetylide ligands adopt a cis coordination mode featuring non-planar terphenyl moieties as revealed by X-ray crystallog. analyses. The electrochem., photophys. and photochem. properties of these platinum(II) complexes have been investigated. These platinum(II) diimine complexes show broad emission with peak maxima from 566 nm to 706 nm, with two of them having emission quantum yields >60% and lifetimes <2μs in solutions at room temperature, whereas the platinum(II) diacetylide complexes having bis-N-heterocyclic carbene instead of diimine ligand display photoluminescence with quantum yields of up to 28% in solutions and excited state lifetimes of up to 62μs at room temperature Application studies revealed that one of the complexes can catalyze photoinduced aerobic dehydrogenation of alcs. and alkenes, and a relatively non-toxic water-soluble Pt(II) complex displays anti-angiogenic activity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Reference of 6-Chloro-2,3-dihydro-1H-indole

The Article related to platinum diacetylide bipyridine imidazolylidene complex preparation photoluminescence photophysics, crystal structure platinum diacetylide bipyridine imidazolylidene complex, mol structure platinum diacetylide bipyridine imidazolylidene complex, bis-n-heterocyclic carbene, diacetylide, diimine, luminescence, platinum and other aspects.Reference of 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhong, Jian-Ji; To, Wai-Pong; Liu, Yungen; Lu, Wei; Che, Chi-Ming published an article in 2019, the title of the article was Efficient acceptorless photo-dehydrogenation of alcohols and N-heterocycles with binuclear platinum(II) diphosphite complexes.Application of 52537-00-5 And the article contains the following content:

Binuclear platinum(II) diphosphite complexes as practical and efficient photocatalysts for oxidant-free and acceptorless dehydrogenation of alcs. and N-heterocycles in high yields even under substrate-limiting conditions was described. The reaction could be used for constructing quinazolin-4(3H)-ones from anthranilamide and alcs. This protocol offered the unique reactivity of binuclear platinum(II) diphosphite complexes, wide substrate scope, mild reaction conditions, scalability, utility and versatility of these photocatalysts with practical relevance. Regeneration of the photocatalyst by means of reductive elimination of dihydrogen from the in-situ formed platinum(III)-hydride species represented an alternative paradigm to the current approach in photoredox catalysis. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to binuclear platinum diphosphite complex preparation uv absorption, ketone aldehyde preparation, alc photodehydrogenation binuclear platinum diphosphite complex catalyst, indole quinoline isoquinoline benzothiazole pyrrole preparation, saturated heterocycle photodehydrogenation binuclear platinum diphosphite catalyst and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 10, 2006, Jolidon, Synese; Narquizian, Robert; Norcross, Roger, David; Pinard, Emmanuel published a patent.Application of 52537-00-5 The title of the patent was Preparation of heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1. And the patent contained the following:

The title compounds I [R1 = halo, cycloalkyl, aryl, etc.; R2 = SO2(alkyl), SO2NH(alkyl), NO2 or CN; het = aromatic or partially aromatic bicyclic amine, which may contain one or two addnl. N-atoms, selected from (un)substituted isoindolyl, indolyl, pyrrolo[3,4-d]pyrimidinyl, etc.], useful for treating illnesses based on the glycine uptake inhibitor, were prepared and formulated. Thus, reacting 2-isopropoxy-5-methansulfonylbenzoic acid (preparation given) with 2,3-dihydro-1H-isoindole afforded 88% II. It has been found that the compounds I are good inhibitors of the glycine transporter 1 (GlyT-1) (IC50 values were given for representative compounds I). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

The Article related to heterocyclyl phenyl methanone preparation glycine transporter glyt1 inhibitor, isoindolyl phenyl methanone preparation glycine transporter glyt1 inhibitor, indolyl phenyl methanone preparation glycine transporter glyt1 inhibitor, pyrrolopyrimidinyl phenyl methanone preparation glycine transporter glyt1 inhibitor and other aspects.Application of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 6, 1986, Henneke, Karl Wilhelm; Wedemeyer, Karlfried published a patent.HPLC of Formula: 52537-00-5 The title of the patent was Procedure for preparing indoline and indoline derivatives. And the patent contained the following:

Indolines I (R1, R2 = H, halo, alkyl, alkoxy; R3 = H, alkyl) were prepared by cyclization of phenethylamines II (X = halo) in the presence of Cu catalysts, characterized in that the cyclization is done in the presence of inorganic carbonates or H carbonates and in the presence of complexing agents for copper ions. Heating a mixture of 2-ClC6H4CH2CH2NH2, CuCl, 8-hydroxyquinoline, soda, and Me2CHCH2OH to boiling and keeping 4-6 h at 120° gave 99.9% pure indoline in 94% yield. Indoline and its derivatives are intermediates for plant protective agents, agrochems., aromas, dyes, and pharmaceuticals. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5

The Article related to indoline, halophenethylamine cyclization cuprous chelator, plant protective intermediate indoline, agrochem protective intermediate indoline, aroma protective intermediate indoline, dye protective intermediate indoline, pharmaceutical protective intermediate indoline, carbonate cyclization halophenethylamine and other aspects.HPLC of Formula: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles