Category: 52537-00-5

On March 26, 2021, Shen, Meng-Lan; Wang, Pu-Sheng; Gong, Liu-Zhu published an article.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole The title of the article was Counteranion-controlled regioselectivity in palladium-catalyzed allylic amination of dienyl allylic carbonates. And the article contained the following:

A regioselective Pd-catalyzed allylic amination reaction of dienyl allylic carbonates and aromatic amines has been developed by means of phosphoramidite-palladium catalysis. The regioselectivity could be altered by the counterion of the π-allylpalladium intermediate. As a result, either branched Z-dienyl allylic amines or linear conjugated allylic amines were generated in high levels of regioselectivity from the same substrates by tuning the reaction conditions. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole

The Article related to aryl amine dienyl allylic carbonate palladium catalyst regioselective amination, dienyl aryl amine preparation diastereoselective, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 5, 2020, Zhao, Fei; Masci, Domiziana; Ferla, Salvatore; Varricchio, Carmine; Brancale, Andrea; Colonna, Serena; Black, Gary W.; Turner, Nicholas J.; Castagnolo, Daniele published an article.Name: 6-Chloro-2,3-dihydro-1H-indole The title of the article was Monoamine Oxidase (MAO-N) Biocatalyzed Synthesis of Indoles from Indolines Prepared via Photocatalytic Cyclization/Arylative Dearomatization. And the article contained the following:

The biocatalytic aromatization of indolines into indole derivatives exploiting monoamine oxidase (MAO-N) enzymes is presented. Indoline substrates were prepared via photocatalytic cyclization of arylaniline precursors or via arylative dearomatization of unsubstituted indoles and in turn chemoselectively aromatized by the MAO-N D11 whole cell biocatalyst. Computational docking studies of the indoline substrates in the MAO-N D11 catalytic site allowed for the rationalization of the biocatalytic mechanism and exptl. results of the biotransformation. This methodol. represents an efficient example of biocatalytic synthesis of indole derivatives and offers a facile approach to access these aromatic heterocycles under mild reaction conditions. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Name: 6-Chloro-2,3-dihydro-1H-indole

The Article related to monoamine oxidase indole indoline photocatalytic cyclization dearomatization, Placeholder for records without volume info and other aspects.Name: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jiang, Hua-Jie; Zhong, Xiu-Mei; Yu, Jie; Zhang, Ying; Zhang, Xinhao; Wu, Yun-Dong; Gong, Liu-Zhu published an article in 2019, the title of the article was Assembling a Hybrid Pd Catalyst from a Chiral Anionic CoIII Complex and Ligand for Asymmetric C(sp3)-H Functionalization.HPLC of Formula: 52537-00-5 And the article contains the following content:

An unusual hybrid palladium catalyst containing an anionic chiral CoIII complex and a chiral phosphoramidite ligand shows a high capacity for catalyzing asym. thioamide-directed C(sp3)-H arylation and delivers excellent yield and enantioselectivity (up to 99% yield, 99% ee). Significant synergy between the chiral ligand and the anion in terms of stereochem. control was observed Mechanistic studies revealed both the nature of the C-H activation and the origin of the enantioselectivity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5

The Article related to palladium catalyst chiral ligand asym functionalization arylation, c−h functionalization, chiral phosphoramidites, cobalt, palladium, synergistic effects, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 23, 2009, Kamikubo, Takashi; Miura, Masanori; Okuda, Takao; Maki, Keisuke; Hirayama, Fukushi; Moritomo, Ayako; Komiya, Yuriko; Matsuura, Keisuke; Ibuka, Ryotaro published a patent.SDS of cas: 52537-00-5 The title of the patent was Preparation of 2-pyridone derivatives as EP4 receptor agonists for treatment of peripheral arterial disease. And the patent contained the following:

The title compounds I [wherein L1 and L2 = independently alkylene, alkenylene, etc.; R1 = substituted aryl or heteroaryl; R2 = (un)substituted alkylamino, heteroarylamino, etc.; R3 – R5 = independently H, halo, CN, alkyl, etc.] or pharmaceutically acceptable salts thereof are prepared as prostanoid receptors type EP4 (EP4) inhibitors for the treatment of peripheral arterial disease. For example, the compound II was prepared in a multi-step synthesis. II inhibited EP4 receptor with IC50 value of 0.52 nM in rat. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5

The Article related to pyridone preparation prostanoid receptor agonist treatment peripheral arterial disease, prostanoid receptor ep4 agonist preparation pyridone, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 27, 2014, Heeres, Andre; Grol, Cornelius Joannes; Borst, Marcus Leonardus Gerardus; Willigers – Hogg, Sandra published a patent.Quality Control of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin 5HT2C receptor modulators and their preparation. And the patent contained the following:

The invention relates to compounds of formula I and pharmaceutically acceptable salts, hydrates and solvates thereof, that have serotonin (5-HT) transporter inhibitory effects and 5-HT2C receptor antagonist or inverse agonist effects. The invention also relates to pharmaceutical compositions comprising these compounds, and methods of using them for application in the prophylaxis or treatment of CNS disorders. Compounds of formula I wherein R1 is C6-24 aryl and C4-24 heteroaryl; R2 and R3 are independently H and C1-12 alkyl; R2R3 taken together to form (un)substituted C2-4 alkylene and heterocyclyl; R4 is (un)substituted C1-5 alkylene; W1 is (un)substituted methylene; NH and derivatives, O and S; R5, R6, R7 and R8 are independently absent, H, halo and C1-12 alkyl; U, X, Y and Z are independently C and N; E is CH, C-C1-6 alkyl, N, NH and derivatives, etc.; dashed bond is single and double bond; L and M are independently (un)substituted methylene, CH, C-C1-6 alkyl, etc.; R10, R11, R12 and R13 are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; and pharmaceutically acceptable salts, hydrates and solvates thereof, are claimed. The invention compounds were evaluated for their serotonin transporter and serotonin HT2C receptor modulatory activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Quality Control of 6-Chloro-2,3-dihydro-1H-indole

The Article related to heteroaryloxypropylamine preparation serotonin transporter 5ht2c receptor modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jiang, Hua-Jie; Zhong, Xiu-Mei; Yu, Jie; Zhang, Ying; Zhang, Xinhao; Wu, Yun-Dong; Gong, Liu-Zhu published an article in 2019, the title of the article was Assembling a Hybrid Pd Catalyst from a Chiral Anionic CoIII Complex and Ligand for Asymmetric C(sp3)-H Functionalization.HPLC of Formula: 52537-00-5 And the article contains the following content:

An unusual hybrid palladium catalyst containing an anionic chiral CoIII complex and a chiral phosphoramidite ligand shows a high capacity for catalyzing asym. thioamide-directed C(sp3)-H arylation and delivers excellent yield and enantioselectivity (up to 99% yield, 99% ee). Significant synergy between the chiral ligand and the anion in terms of stereochem. control was observed Mechanistic studies revealed both the nature of the C-H activation and the origin of the enantioselectivity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5

The Article related to palladium catalyst chiral ligand asym functionalization arylation, c−h functionalization, chiral phosphoramidites, cobalt, palladium, synergistic effects, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 23, 2009, Kamikubo, Takashi; Miura, Masanori; Okuda, Takao; Maki, Keisuke; Hirayama, Fukushi; Moritomo, Ayako; Komiya, Yuriko; Matsuura, Keisuke; Ibuka, Ryotaro published a patent.SDS of cas: 52537-00-5 The title of the patent was Preparation of 2-pyridone derivatives as EP4 receptor agonists for treatment of peripheral arterial disease. And the patent contained the following:

The title compounds I [wherein L1 and L2 = independently alkylene, alkenylene, etc.; R1 = substituted aryl or heteroaryl; R2 = (un)substituted alkylamino, heteroarylamino, etc.; R3 – R5 = independently H, halo, CN, alkyl, etc.] or pharmaceutically acceptable salts thereof are prepared as prostanoid receptors type EP4 (EP4) inhibitors for the treatment of peripheral arterial disease. For example, the compound II was prepared in a multi-step synthesis. II inhibited EP4 receptor with IC50 value of 0.52 nM in rat. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5

The Article related to pyridone preparation prostanoid receptor agonist treatment peripheral arterial disease, prostanoid receptor ep4 agonist preparation pyridone, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 27, 2014, Heeres, Andre; Grol, Cornelius Joannes; Borst, Marcus Leonardus Gerardus; Willigers – Hogg, Sandra published a patent.Quality Control of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin 5HT2C receptor modulators and their preparation. And the patent contained the following:

The invention relates to compounds of formula I and pharmaceutically acceptable salts, hydrates and solvates thereof, that have serotonin (5-HT) transporter inhibitory effects and 5-HT2C receptor antagonist or inverse agonist effects. The invention also relates to pharmaceutical compositions comprising these compounds, and methods of using them for application in the prophylaxis or treatment of CNS disorders. Compounds of formula I wherein R1 is C6-24 aryl and C4-24 heteroaryl; R2 and R3 are independently H and C1-12 alkyl; R2R3 taken together to form (un)substituted C2-4 alkylene and heterocyclyl; R4 is (un)substituted C1-5 alkylene; W1 is (un)substituted methylene; NH and derivatives, O and S; R5, R6, R7 and R8 are independently absent, H, halo and C1-12 alkyl; U, X, Y and Z are independently C and N; E is CH, C-C1-6 alkyl, N, NH and derivatives, etc.; dashed bond is single and double bond; L and M are independently (un)substituted methylene, CH, C-C1-6 alkyl, etc.; R10, R11, R12 and R13 are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; and pharmaceutically acceptable salts, hydrates and solvates thereof, are claimed. The invention compounds were evaluated for their serotonin transporter and serotonin HT2C receptor modulatory activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Quality Control of 6-Chloro-2,3-dihydro-1H-indole

The Article related to heteroaryloxypropylamine preparation serotonin transporter 5ht2c receptor modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 3, 2010, Staehle, Wolfgang; Kober, Ingo; Schiemann, Kai; Schultz, Melanie; Wienke, Dirk published a patent.Category: indole-building-block The title of the patent was Preparation of benzo[b][1,6]naphthyridines as inhibitors of autotaxin for the treatment of tumors. And the patent contained the following:

Title compounds I [D = D'[R1]m; D’ = Ar, Het1; Het1 = heterocycle with provisos; R1 = H, halo, OH, etc.; R4 = [R4′]p; R4′ = H, halo, OH, etc.; m = 0-5; p = 1-4; R2, R3 = alkyl with provisos; R5 = H, halo, OH, etc.; X, Y = CH2, (CH2)2, CO, etc.; Z = O, NH, CH=CH, etc.] and their pharmaceutically acceptable salts and formulations were prepared Benzo[b][1,6]naphthyridine II is an example from the disclosed process. Title compounds I exhibited inhibition activity in autotaxin assays. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Category: indole-building-block

The Article related to benzonaphthyridine preparation autotaxin inhibition antitumor agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles