Category: 52562-50-2

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (i) Preparation of the imines The aldehydes (0.20mmol) and 1,2-diaminoanthraquinone (0.24mmol) were dissolved separately in ethanol (4ml/mmol). The ethanolic solution of aldehyde and formic acid (0.04 ml/mmol of aldehyde) was added to the solution of 1,2-diaminoanthraquinone heated at reflux. The reaction mixture was heated under reflux overnight. (ii) Cyclisation of the imines After cooling, the ethanolic solution was evaporated and the crude imine was dissolved in a small volume of acetic acid (5 ml/mmol of imine). To this solution, lead tetraacetate was added (0.20mmol) and the mixture was stirred overnight at room temperature. Addition of water to the reaction mixture gave a solid which was isolated by filtration and purified by recrystalisation from diethyl ether/chloroform., 52562-50-2

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Batista, Rosa M.F.; Oliveira, Elisabete; Costa, Susana P.G.; Lodeiro, Carlos; Raposo, M. Manuela M.; Supramolecular Chemistry; vol. 26; 2; (2014); p. 71 – 80;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52562-50-2, General procedure: A mixture of 1 (20 mmol) and 2 (10 mmol) and water (5 ml) was refluxed at 100 C1 h. At the end of this period, an orange-colored solid was separated from the reaction mixture which was collected by filtration. The isolated solid was washed with hot water (10 ml 9 3), dried, and recrystallized from ethanol to obtain pure 4.

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Madhu, Bandi; Raja sekar; Venkata Ramana Reddy; Dubey; Research on Chemical Intermediates; vol. 43; 12; (2017); p. 6993 – 7012;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52562-50-2,5-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

52562-50-2, General procedure: An equimolar mixture of Gewald adducts (5CN, 6CN, 7CN and 8CN) and substituted indole-carboxaldehydes in absolute ethanol with 0.5 mL of acetic acid was stirred under room temperature for 24 hs. Water was addedand the solid that precipitated out was filtered under vacuum, washed with water, dried and recrystallized from absolute ethanol (Scheme 1) according previously methodology [20].

As the paragraph descriping shows that 52562-50-2 is playing an increasingly important role.

Reference£º
Article; Felix, Mayara B.; de Souza, Edson R.; de Lima, Maria do C.A.; Frade, Daiana Karla G.; Serafim, Vanessa de L.; Rodrigues, Klinger Antonio da F.; Neris, Patricia Lima do N.; Ribeiro, Frederico F.; Scotti, Luciana; Scotti, Marcus T.; de Aquino, Thiago M.; Mendonca Junior, Francisco Jaime B.; de Oliveira, Marcia R.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 3972 – 3977;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52562-50-2, 1-(3-Chloropropyl)-5-methyl-indole-3-carboxaldehyde 1-(3-Chloropropyl)-5-methyl-indole-3-carboxaldehyde was prepared from 5-methylindole-3-carboxaldehyde according to the method described in Example 1 to give 2.26 g (76%) of the product as an off-white solid: mp 89-90 C.; IR numax (Nujol)/cm-1 2956, 1659, 1536, 1403, 1171, 820 and 786; NMR deltaH (400 MHz, CDCl3) 2.27-2.34 (2H, m), 2.47 (3H, s), 3.46 (2H, t, J 6.2 Hz), 4.38 (2H, t, J 6.6 Hz), 7.16 (1H, d, J 10 Hz), 7.28 (1H, d, J 8.4 Hz), 7.70 (1H, s), 8.12 (1H, s) and 9.97 (1H, s); Found: C, 66.12; H, 6.00; N, 5.88%. C13H14ClNO requires: C, 66.24; H, 5.99; N, 5.94%.

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Vernalis Research Limited; US6433175; (2002); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles