Category: 5318-27-4

5318-27-4, 6-Aminoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Five mmol 2,4-dichloro-5-substitued-pyrimidines (8a-8g) or 4,6-dichloro-1H-pyrazolo [3,4-d]pyrimidine (8h) and DIPEA (1.2mL, 7.5mmol) were dissolved in DMF (4mL) and cooled to -60C. Indol-5-amine or amines 9a-9i (5mmol) dissolved in DMF (2mL) were added dropwise. The reaction mixture was stirred at -60C for about 1h. Next, the cooling bath was removed, the reaction mixture was stirred at room temperature for 2h, and was poured to 10mL cooled water after the reaction was complete as monitored by TLC. The formed precipitate was collected by filtration, washed with ethanol yielding compounds 10a-10h, 11a-11j, which were dried and used in the next step without further purification., 5318-27-4

5318-27-4 6-Aminoindole 256096, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Lingfeng; Fu, Weitao; Feng, Chen; Qu, Rong; Tong, Linjiang; Zheng, Lulu; Fang, Bo; Qiu, Yinda; Hu, Jie; Cai, Yuepiao; Feng, Jianpeng; Xie, Hua; Ding, Jian; Liu, Zhiguo; Liang, Guang; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 510 – 527;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

5318-27-4, 6-Aminoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A flask was charged with 6-amino Indole (1eq.) in the presenceof dichloromethane (DCM, 0.5 M) and E3N (1.2 eq.) under nitrogenat 0 C. This was followed by addition of substituted benzoylchlorides (1 eq.) to stir at room temperature overnight. The reactionmixture was quenched by water to be extracted with ethyl acetateand dried over anhydrous Na2SO4. The ethyl acetate layer wasevaporated in vacuo. The crude product was purified using silica gelcolumn chromatography using ethyl acetate/hexane solventmixture (50:50) to obtain substituted N-(1H-indole-6-yl) benzamidederivatives

5318-27-4, As the paragraph descriping shows that 5318-27-4 is playing an increasingly important role.

Reference£º
Article; Hendy, Moataz S.; Ali, Aya A.; Ahmed, Lubna; Hossam, Reham; Mostafa, Alaa; Elmazar, Mohamed M.; Naguib, Bassem H.; Attia, Yasmeen M.; Ahmed, Mahmoud Salama; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 281 – 290;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles