53462-88-7, Methyl 3-formyl-1H-indole-4-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
53462-88-7, A) 2.1 g of 80% pure sodium hydride were added in portions to a solution of 7 g of methyl 3-formylindole-4-carboxylate (see Example 1A for preparation) in 250 ml of dry dimethylformamide at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at 50 C. for 1 hour. Subsequently, 7 ml of methyl iodide was added through a dropping funnel, and the reaction mixture was stirred at 50 C. for a further 2 hours. To work up the reaction mixture it was evaporated to dryness under reduced pressure and taken up in a mixture of 50 ml of water and 50 ml of dichloromethane. The dichloromethane phase was separated, and the aqueous phase was extracted once more with 50 ml of dichloromethane. The organic phases were combined, dried over sodium sulfate, filtered and evaporated. The remaining crystalline crude product was recrystallized from diethyl ether. Drying of the crystals resulted in 6.9 g of methyl 1-methyl-3-formylindole-4-carboxylate with a melting point of 128-129 C.
The synthetic route of 53462-88-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Kali-Chemie Pharma GmbH; US5272143; (1993); A;,
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