Category: 53716-50-0

Related Products of 53716-50-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 53716-50-0, Name is Oxfendazole, SMILES is O=C(OC)NC1=NC2=CC=C(S(C3=CC=CC=C3)=O)C=C2N1, belongs to indole-building-block compound. In a article, author is Peytam, Fariba, introduce new discover of the category.

Eighteen dihydroindolizino[8,7b]indole derivatives 4a-r were designed, synthesized and evaluated as new alpha-glucosidase inhibitors. These derivatives were synthesized by an efficient one-pot two-step reaction under mild condition. All the synthesized compounds were found to be more active than the standard drug acarbose (IC50 = 750.0 +/- 1.5 mu M) with IC50 values in the range of 107.2 +/- 1.0-275.4 +/- 1.5 mu M. Among the synthesized compounds, diethyl derivative 4o and dimethyl derivative 4 h exhibited the highest anti-alpha-glucosidase activities (IC50 = 107.2 +/- 1.0 and 118.0 +/- 0.7 mu M, respectively). Kinetic analysis of the compound 4o revealed that this compound is a competitive inhibitor for alpha-glucosidase with Ki value of 113 mu M. Furthermore, the docking study on the compounds 4o and 4 h revealed that these compounds interacted with the important residues in the active site of the homology model of alpha-glucosidase. (C) 2020 Elsevier B.V. All rights reserved.

Related Products of 53716-50-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 53716-50-0.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: https://www.ambeed.com/products/53716-50-0.html, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53716-50-0, Name is Oxfendazole, molecular formula is C15H13N3O3S. In an article, author is Wahsner, Jessica,once mentioned of 53716-50-0.

Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, Ga-68-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7 fold higher than in control groups and that uptake is linearly correlated (R-2 = 0.98) with the concentration of lung allysine.

If you’re interested in learning more about 53716-50-0. The above is the message from the blog manager. HPLC of Formula: https://www.ambeed.com/products/53716-50-0.html.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 53716-50-0, Name is Oxfendazole, formurla is C15H13N3O3S. In a document, author is Vasin, Andrey G., introducing its new discovery. Formula: C15H13N3O3S.

Synthesis and antiproliferative activity of salicylidenehydrazones based on indole-2(3)-carboxylic acids

A series of indole-2(3)-carboxylic acid hydrazones were synthesized and their antiproliferative activity was studied for the K562 leukemia, MCF7 breast adenocarcinoma, and HCT116 colon carcinoma cell lines and resistant HCT116p53KO subline in order to preliminary screen biological properties and to reveal the role of the aldehyde fragment and heterocycle in the ability of compounds to inhibit tumor growth. A number of derivatives have been identified that inhibit the growth of tumor cells in submicromolar concentrations, promising for further optimization and in-depth study of antitumor properties.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 53716-50-0 help many people in the next few years. Formula: C15H13N3O3S.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthetic Route of 53716-50-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 53716-50-0, Name is Oxfendazole, SMILES is O=C(OC)NC1=NC2=CC=C(S(C3=CC=CC=C3)=O)C=C2N1, belongs to indole-building-block compound. In a article, author is Coulson, Thomas J. D., introduce new discover of the category.

Characterization of the TyrR Regulon in the Rhizobacterium Enterobacter ludwigii UW5 Reveals Overlap with the CpxR Envelope Stress Response

The TyrR transcription factor controls the expression of genes for the uptake and biosynthesis of aromatic amino acids in Escherichia coli. In the plant associated and clinically significant proteobacterium Enterobacter ludwigii UW5, the TyrR orthologue was previously shown to regulate genes that encode enzymes for synthesis of the plant hormone indole-3-acetic acid and for gluconeogenesis, indicating a broader function for the transcription factor. This study aimed to delineate the TyrR regulon of E. ludwigii by comparing the transcriptomes of the wild type and a tyrR deletion strain. In E. ludwigii, TyrR positively or negatively regulates the expression of over 150 genes. TyrR downregulated expression of envelope stress response regulators CpxR and CpxP through interaction with a DNA binding site in the intergenic region between divergently transcribed cpxP and cpxR. Repression of cpxP was alleviated by tyrosine. Methyltransferase gene dmpM, which is possibly involved in antibiotic synthesis, was strongly activated in the presence of tyrosine and phenylalanine by TyrR binding to its promoter region. TyrR also regulated expression of genes for aromatic catabolism and anaerobic respiration. Our findings suggest that the E. ludwigii TyrR regulon has diverged from that of E. coli to include genes for survival in the diverse environments that this bacterium inhabits and illustrate the expansion and plasticity of transcription factor regulons. IMPORTANCE Genome-wide RNA sequencing revealed a broader regulatory role for the TyrR transcription factor in the ecologically versatile bacterium Enterobacter ludwigii beyond that of aromatic amino acid synthesis and transport that constitute the role of the TyrR regulon of E. coli. In E. ludwigii, a plant symbiont and human gut commensal, the TyrR regulon is expanded to include genes that are beneficial for plant interactions and response to stresses. Identification of the genes regulated by TyrR provides insight into the mechanisms by which the bacterium adapts to its environment.

Synthetic Route of 53716-50-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 53716-50-0.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles