Category: 5388-42-1

Studies on the syntheses of heterocyclic compounds. Part 742. Studies on the syntheses of analgesics. Part 50. Synthesis of optically active 2-[4-(1-oxo-2-isoindolinyl)phenyl]propanoic acid was written by Kametani, Tetsuji;Kigasawa, Kazuo;Hiiragi, Mineharu;Ishimaru, Haruhide;Haga, Seiji;Shirayama, Keiko. And the article was included in Journal of Heterocyclic Chemistry in 1978.Name: 2-Phenylisoindolin-1-one This article mentions the following:

Analgesic and antiinflammatory I (R = CHMeCO₂H), prepared from I (R = COMe) (II) via oxidation of I (R = CHMeCOCO₂H) (III) or hydrolysis of I (R = Q, R¹ = H, R² = CH), was resolved via diastereoisomeric salts with cinchonidine. III was obtained from II in 5 steps via I [R = CMe:C(CN)CO₂Et; Q, where R¹ = CO₂NH₂, R² = CO₂Et and R¹ = CONH₂, R² = CO₂Na; R = COCONH₂] or by Darzens reaction of II with ClCH₂CO₂Et and treatment of the resulting I (R = Q, R¹ = H, R² = CO₂Et) with concentrated HCl and HOAc. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Name: 2-Phenylisoindolin-1-one).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 2-Phenylisoindolin-1-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Site-selective Ru-catalyzed C-H bond alkenylation with biologically relevant isoindolinones: a case of catalyst performance controlled by subtle stereo-electronic effects of the weak directing group was written by Yuan, Yu-Chao;Bruneau, Christian;Roisnel, Thierry;Gramage-Doria, Rafael. And the article was included in Catalysis Science & Technology in 2019.Recommanded Product: 5388-42-1 This article mentions the following:

Alkenylated isoindolinones I [R = CO₂Me, Ph, 4-FC₆H₄, etc.; R¹ = H; R² = H, Me, Cl, MeO, CN, CO₂Et; R³ = R⁴ = H, Me, MeO; R¹R² = OCH₂O] were prepared via site-selective Ru-catalyzed C-H bond alkenylation of isoindolinones with alkenes. Notably, besides the presence of two aromatic C-H sites available for functionalization, selective mono-alkenylation in the ortho-position with respect to the nitrogen atom were achieved with a readily available ruthenium catalyst. The scalability, versatility and high functional group tolerance of the catalysis enabled the late-stage functionalization of biol. relevant indoprofen and further derivatizations. Preliminary mechanistic studies indicated, the ease of the C-H bond activation step, the key role of the carbonyl group as a weak directing group throughout the catalytic cycle and the unexpected subtle differences associated between cyclic amides and imides as weak directing groups in ruthenium-catalyzed C-H bond alkenylation reactions. The isolation and role of an unprecedented off-cycle ruthenium complex was discussed as well. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Recommanded Product: 5388-42-1).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 5388-42-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Carbene and radical pathways in pyrolysis of benzisoxazolones and benzotriazoles was written by Prager, Rolf H.;Baradarani, Mehdi M.;Khalafy, Jabbar. And the article was included in Journal of Heterocyclic Chemistry in 2000.Product Details of 5388-42-1 This article mentions the following:

Conference proceedings containing review material. A comparative study of the flash vacuum pyrolysis of a number of N-alkyl- and N-acylbenzotriazoles and -benzisoxazolones has confirmed that carbene-derived pathways predominate at lower temperatures, and radical pathways at higher temperatures Two new general unimol. thermal reactions are also highlighted. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Product Details of 5388-42-1).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 5388-42-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reactions of imides with samarium(II) iodide was written by Brandukova, N. E.;Vygodskii, Ya. S.;Komarova, L. I.;Strelkova, T. V.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1996.Category: indole-building-block This article mentions the following:

One of the carbonyl groups of N-phenylphthalimide is reduced by SmI₂ to a CHOH or CH₂ group at ∼20°. The reaction pathway depends mainly on the reactant ratio and the sequence of reactant addition to the reaction mixture Under similar conditions, both CO groups of N-acetylcaprolactam are reduced by SmI₂, whereas the CO group of ε-caprolactam is not reduced. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Category: indole-building-block).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles