Category: 5416-80-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5416-80-8,2-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of 2-methylindole-3-carboxaldehyde (7a) (200 mg, 1.26 mmol) and Cs2CO3 (1.34 g, 3.80 mmol) in N,N-dimethylformamide (4 mL) was added 2-fluorobenzaldehyde (210 muL, 1.99 mmol) under a nitrogen atmosphere. The reaction mixture was heated at 140 C until the indole substrate was all consumed (monitored by TLC), and then allowed to cool down to room temperature. The resulting mixture was filtered and washed with ethyl acetate (80 mL). The filtrate was washed with water (3 X 80 mL). The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (EtOAc/hexanes = 1:3) to afford the desired indolo[1,2-a]quinoline., 5416-80-8

The synthetic route of 5416-80-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Thanetchaiyakup, Adisak; Rattanarat, Hassayaporn; Chuanopparat, Nutthawat; Ngernmeesri, Paiboon; Tetrahedron Letters; vol. 59; 11; (2018); p. 1014 – 1018;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5416-80-8,2-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

INTERMEDIATE 9 – PREPARATION OF 3-(5-Chloro-1 H-indol-3-yl)propan-1-amine. To a solution of 3-(3-Azidopropyl)-5-chloro-1 H-indole (0.299 g; 1.27 mmol) in THF (9 mL) were added triphenylphosphine (0.354 g; 1.34 mmol) and water (0.6 mL). The reaction mixture was stirred at room temperature for 22 hours and was then concentrated under reduced pressure. The residue was dissolved in dichloromethane (10 mL) and 10 mL of 6N hydrochloric acid were added. After separation, the aqueous layer was further extracted with dichloromethane (2×10 mL) and the pH was adjusted to 14 with an aqueous solution of sodium hydroxide 6N. This basic solution was extracted dichloromethane (3×20 mL) and the combined organic layer was dried over magnesium sulphate, and evaporated to afford 0.089 g (34%) of 3-(5-Chloro-1 H-indol-3-yl)propan-1 -amine as a white solid.ESI/APCI(+): 209 (M+H); ESI/APCI(-): 207 (M-H).

5416-80-8, 5416-80-8 2-Methyl-1H-indole-3-carbaldehyde 73166, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D; REMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick; WO2012/80220; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

5416-80-8, 2-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-Methyl-indole-3-carbaldehyde (1) (2.1?g, 10.0mmoles) in Benzene (50?mL) containing 50% NaOH solution (25?mL), tetrabutylammonium hydrogensulfate (100?mg) and P-Toluenesulfonyl chloride (1.31?g, 10.0mmoles) were added. The mixture was stirred well for 4?h. hen it was poured over crushed ice and extracted with ethyl acetate (3?*?50?mL). The organic layer was separated, washed with water (3?*?25?mL) and dried (MgSO4). Crystallization process by slow solvent evaporation technique using ethyl acetate gave the desired product in 87% yield., 5416-80-8

As the paragraph descriping shows that 5416-80-8 is playing an increasingly important role.

Reference£º
Article; Bellamkonda, Yagna Narayana; Vijaya Chamundeeswari; Journal of Molecular Structure; vol. 1181; (2019); p. 613 – 626;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

5416-80-8, 2-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a suspension of 2-methylindole-3-carboxaldehyde (7a) (200 mg, 1.26 mmol) and Cs2CO3 (1.34 g, 3.80 mmol) in N,N-dimethylformamide (4 mL) was added 2-fluorobenzaldehyde (210 muL, 1.99 mmol) under a nitrogen atmosphere. The reaction mixture was heated at 140 C until the indole substrate was all consumed (monitored by TLC), and then allowed to cool down to room temperature. The resulting mixture was filtered and washed with ethyl acetate (80 mL). The filtrate was washed with water (3 X 80 mL). The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (EtOAc/hexanes = 1:3) to afford the desired indolo[1,2-a]quinoline.

5416-80-8, The synthetic route of 5416-80-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Thanetchaiyakup, Adisak; Rattanarat, Hassayaporn; Chuanopparat, Nutthawat; Ngernmeesri, Paiboon; Tetrahedron Letters; vol. 59; 11; (2018); p. 1014 – 1018;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles