Category: 5457-28-3

5457-28-3, 1H-Indole-3-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5457-28-3, General procedure: Enone 1a (62.5 mg, 0.3 mmol), 3-cyanoindole (51.2 mg, 0.36mmol, 1.2 equiv), KOH (0.8 mg, 0.015 mmol, 5.0 mol%), and CH2Cl2 (3.0 mL) were sequentially charged into a dry round-bottomedflask (25 mL). The reaction mixture was stirred at 25 Cuntil the reaction complete (monitored by TLC). The reactionmixture was diluted with CH2Cl2 (3.0 mL), and washed withbrine (3 ¡Á 4.0 mL). The aqueous phase was extracted withCH2Cl2 (4.0 mL). The organic phase was combined, dried withanhydrous Na2SO4, and concentrated under reduced pressure.The residue was purified by flash column chromatography onsilica gel (PE-EtOAc, 6:1) to afford the pure product 2a.

The synthetic route of 5457-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Jingya; Li, Tianyuan; Zhou, Hongyan; Li, Nana; Xie, Dongtai; Li, Zheng; Synlett; vol. 28; 10; (2017); p. 1227 – 1231;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5457-28-3,1H-Indole-3-carbonitrile,as a common compound, the synthetic route is as follows.

To a 1 L four-neck flask were added dioxane (200 mL), THF (100 mL) and 3- cyanoindole (30 g, 211 mmol). The solution was cooled to 0 oC and LiAlH4 (30 g, 780 mmol) was added portion-wise. After stirring at 0 oC for 10 minutes, the mixture was heated to reflux for 0.5 h until TLC showed completion. The mixture was carefully quenched with water (300 mL) at 0 oC, filtered, and the filtrate was separated. The aqueous layer was extracted with EA (500 mL x 2). The combined organic layers were dried over sodium sulfate, concentrated and washed with PE/EA to give 3-aminomethylindole (21 g, 70percent) as a brick red solid. (2137) 1H NMR (300 MHz, DMSO-d6) 10.80 (br, 1 H), 7.59 (d, J = 7.5 Hz, 1 H), 7.34 (d, J = 8.1 Hz, 1 H), 7.20 (s, 1 H), 7.09- 7.04 (m, 1 H), 6.99- 6.94 (m, 1 H), 3.87 (s, 2 H)., 5457-28-3

5457-28-3 1H-Indole-3-carbonitrile 230282, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; CS PHARMASCIENCES, INC.; SONG, Yuntao; BRDIGES, Alexander, James; (524 pag.)WO2017/120429; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5457-28-3,1H-Indole-3-carbonitrile,as a common compound, the synthetic route is as follows.,5457-28-3

To a solution of 3-cyanoindole (1.0 g, 7.03 mmol) in DMC (10 ML), DABCO (0.079 g, 0.70 mmol) is added and the resulting solution is heated to reflux for 8 h.The reaction is cooled to RT, and diluted with EtOAc (40 ML) and H2O (40 ML).The organic layer is separated and washed in sequence with H2O (50 ML), 10% aqueous citric acid (2*40 ML) and H2O (4*40 ML).The organic layer is dried over anhydrous Na2SO4, filtered and concentrated under vacuum to give 3-cyano-1-methylindole (about 1.08 g, 98%) as an oil: 1H NMR (CDCl3) delta 7.74 (d, 1H), 7.53 (s, 1H), 7.40-7.28 (m, 3H), 3.83 (s, 3H); 13C NMR (CDCl3) 136.0, 135.6, 127.8, 123.8, 122.1, 119.8, 116.0, 110.4, 85.4, 33.6; MS m/z 156 [M+1]+.

5457-28-3 1H-Indole-3-carbonitrile 230282, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Dell, Steven; Lozanov, Mario Emilov; Shieh, Wen-Chung; US2004/59131; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles