Category: 5654-93-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5654-93-3,3-Methyl-7-azaindole,as a common compound, the synthetic route is as follows.

[0517] (b) Ethyl 3-(3-methyl-lH-pyrrolo[2,3-b]pyridin-l-yl)propanoate: To a stirred solution of 3-methyl-lH-pyrrolo[2,3-b]pyridine (95 mg, 0.72 mmol), Cs2CO3 (468 mg, 1.44 mmol) in DMF (2 mL) was added ethyl acrylate (0.078 mL, 0.72 mmol). The reaction mixture was stirred overnight at room temperature. The reaction was diluted with EtOAc and washed with water, brine and dried (Na2SO4). Concentration provided a viscous orange oil (150 mg) which was used without additional purification.

5654-93-3, 5654-93-3 3-Methyl-7-azaindole 10931471, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O’GRADY, Harold; WO2010/132615; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

5654-93-3, 3-Methyl-7-azaindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5654-93-3

Example 19A 3-Methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide A little at a time, 3.00 g (22.70 mmol) of 3-methyl-1H-pyrrolo[2,3-b]pyridine (Hands, David; Bishop, Brian; Cameron, Mark; Edwards, John S.; Cottrell, Ian F.; Wright, Stanley H. B.; Synthesis 1996, 877-882.) are added to a solution of 10.45 g (45.40 mmol) of meta-chloroperoxybenzoic acid in 250 ml of dichloromethane, and the mixture is stirred at 10 C. for 2 h. Addition of methanol gives a clear solution which is subjected directly to column chromatography on silica gel (mobile phase: dichloromethane/methanol 100:4 to 3:1). A further purification step by preparative HPLC yields the target compound. Yield: 1.4 g (42% of theory) LC-MS (Method 3): Rt=1.22 min. MS (ESI pos.): m/z=149 [M+H]+. 1H-NMR (DMSO-d6, 400 MHz): delta=2.25 (s, 3H), 7.05 (dd, 1H), 7.22 (s, 1H), 7.60 (d, 1H), 8.10 (d, 1H), 11.97 (br. s, 1H).

The synthetic route of 5654-93-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles