With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57476-50-3,1-Boc-3-Formylindole,as a common compound, the synthetic route is as follows.
STR51 2-(N-Boc-3-Indolyl)-4-quinolinecarboxylic Acid To a 500 mL round bottom flask was added 27.2 g (0.31 mol) of pyruvic acid (Lancaster), N-Boc-indole-3-carboxaldehyde (0.16 mol) and 200 mL of acetic acid. The reaction mixture was heated at 85 C. until all the solid material had dissolved (~30 min). Then aniline (0.31 mol) was added and the reaction mixture was stirred for 90 minutes at 85 C. The precipitate was filtered hot in a fritted funnel and washed with acetic acid (2*50 mL) and then with ether (2*50 mL). The solid filter cake was dried in vacuo to yield 2-(N-Boc-3-indolyl)-4-quinolinecarboxylic Acid (3-50% yield) of pure (>95%) material.
As the paragraph descriping shows that 57476-50-3 is playing an increasingly important role.
Reference£º
Patent; Sepracor, Inc.; US6103905; (2000); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles