Category: 57817-04-6

Demerson, Christopher A.; Humber, Leslie G.; Philipp, Adolph H.; Martel, Rene R. published an article in 1976, the title of the article was Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids.Safety of 7-Isopropyl-1H-indole And the article contains the following content:

Of 37 title compounds, prepared by the condensation of a substituted tryptophol with the appropriate β-keto ester, etodolic acid (I) [41340-25-4], II [57817-27-3], III [57817-28-4], and IV [57817-29-5] were considerably more active than phenylbutazone [50-33-9] and approached the activity of indomethacin [53-86-1] against a chronic rat model of inflammation. The compounds, which were more potent against chronic inflammation than in the carrageenin paw edema test, had relatively low acute ulcerogenic potential in rats. Structure-activity relations were discussed. The experimental process involved the reaction of 7-Isopropyl-1H-indole(cas: 57817-04-6).Safety of 7-Isopropyl-1H-indole

The Article related to inflammation inhibitor tetrahydropyranoindoleacetate, pyranoindoleacetate antiinflammatory, Pharmacodynamics: Structure-Activity and other aspects.Safety of 7-Isopropyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On April 1, 1989, Muratake, Hideaki; Natsume, Mitsutaka published an article.Synthetic Route of 57817-04-6 The title of the article was Preparation of alkyl-substituted indoles in the benzene portion. Part 2. And the article contained the following:

Tosylpyrroles I (R1 = H, Me; R2 = H, Me, prenyl; R3 = alkyl, Ph, vinyl, protected CH2CH2CHO, H; Ts = tosyl) were treated with H2SO4 to give indoles II (R4 = Ts), which were converted to II (R4 = H). I were prepared from 1-tosyl-2-pyrrolecarboxaldehyde and 2-[3-(1,3-dioxolan-2-yl)propionyl]-1-tosylpyrrole. The experimental process involved the reaction of 7-Isopropyl-1H-indole(cas: 57817-04-6).Synthetic Route of 57817-04-6

The Article related to indole alkyl, alkylindole, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 57817-04-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles