With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58665-00-2,Methyl 2-(1-methyl-1H-indol-3-yl)acetate,as a common compound, the synthetic route is as follows.
58665-00-2, A solution of 2-(trifluoromethyl) aniline (161 mg, 1 mmol) in 5 ml of dry tetrahydrofuran was added via syringe to a vigorously stirred mixture of (L-METHYL-LH- indol-3-yl) -acetic acid methyl ester (4 mmol) and LDA (4 mmol, freshly prepared from DIISOPROPYLAMINE and n-BuLi) in 20 ml of dry THF AT-78 C under argon. The mixture was allowed to warm to room temperature and stirred for an additional 4 H. The resulting solution was concentrated in vacuo. The residue was partitioned between ETOAC, and concentrated aqueous NH4C1, and the aqueous layer was extracted with EtOAc. Combined organic extracts were dried over NA2S04, concentrated I71 vacuo, and purified by column chromatography (Silica gel, HEXANE/ETOAC = 1 : 3) to afford analytically pure 4-fluoro-3- (1-methyl-1H-indol-3-yl)-1H-quinolin-2-one.
The synthetic route of 58665-00-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IMCLONE SYSTEMS INCORPORATED; WO2004/89930; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles