Knepper, Kerstin; Brase, Stefan published their research in Organic Letters on August 7 ,2003. The article was titled 《Bartoli Indole Synthesis on Solid Supports》.Synthetic Route of C9H6ClNO2 The article contains the following contents:
Bartoli indole synthesis was performed on solid supports. Starting from Merrifield resin, immobilization of five nitrobenzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic cleavage leads to substituted Me indolecarboxylates in excellent purities. Features of this reaction are the stability of halide groups, ester moieties, and tolerance of o,o’-unsubstituted nitro resins. Heck and Sonogashira reactions are also possible with immobilized indoles. In the part of experimental materials, we found many familiar compounds, such as 7-Chloro-1H-indole-4-carboxylic acid(cas: 588688-45-3Synthetic Route of C9H6ClNO2)
7-Chloro-1H-indole-4-carboxylic acid(cas: 588688-45-3) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C9H6ClNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles