Category: 59132-30-8

In 1976,Journal of Food Science included an article by Chu, N. T.; Clydesdale, F. M.. Computed Properties of C13H12N2O4. The article was titled 《Reactions between amino acids and organic acids: reaction of tryptophan and pyruvic acid》. The information in the text is summarized as follows:

Pyruvic acid reacted with tryptophan, to give yellow products. Four compounds were isolated: 3 were identified as 1,2,3,4-tetrahydroharman-1,3-dicarboxylic acid, an isomer of 1,2,3,4-tetrahydroharman-1,3-dicarboxylic acid and harman. The compound not fully identified, was a yellow polymer. The ratio of pyruvic acid to tryptophan used in this reaction was approx. 1.6:1. The reaction proceeded via a 1:1 mol. reaction between tryptophan and pyruvic acid to form 1,2,3,4-tetrahydroharman-1,3-dicarboxylic acid and its yellow isomer followed by the formation of a yellow polymer produced by the interaction of the yellow isomer of 1,2,3,4-tetrahydroharman-1,3-dicarboxylic acid and pyruvic acid. In the experiment, the researchers used many compounds, for example, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Computed Properties of C13H12N2O4)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Computed Properties of C13H12N2O4They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Tetrahydro-β-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay》 was written by Herraiz, Tomas; Galisteo, Juan. Safety of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid And the article was included in Free Radical Research on August 31 ,2002. The article conveys some information:

Tetrahydro-β-carboline alkaloids that occur in foods such as wine, seasonings, vinegar and fruit products (juices, jams) acted as good radical scavengers (hydrogen- or electron donating) in the ABTS (2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay, and therefore, they could contribute to the beneficial antioxidant capacity attributed to foods. In contrast, the fully aromatic β-carbolines norharman and harman did not show any radical scavenger activity in the same assay. During the reaction with ABTS + radical cation, tetrahydro-β-carboline-3-carboxylic acid such as 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) and 1-methyl-1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid (MTCA-COOH) were converted to harman, whereas 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (THCA) and 1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid (THCA-COOH) afforded norharman. These results suggest that food and naturally-occurring tetrahydro-β-carboline alkaloids if accumulated in tissues, as reported elsewhere, might exhibit antioxidant activity. In the experimental materials used by the author, we found 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Safety of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Safety of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acidThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Identification of β carbolines isolated from fluorescent human lens proteins》 was published in Nature (London, United Kingdom) in 1976. These research results belong to Dillon, James; Spector, Abraham; Nakanishi, Koji. Application of 59132-30-8 The article mentions the following:

The fluorescent 43,000 mol. weight protein (C1) obtained on alk. degradation of the insoluble or high mol. weight protein fraction of human lens gave 2 fully aromatic β-carbolines (I and II) on decomposition or oxidation These β-carbolines were also obtained on decomposition or oxidation of 3,4-dihydro-β-carboline 3-carboxylic acids (III and IV) showing that C1 is a mit. of III and IV. Protein hydrolysates from 45- and 77-year-old but not young human lens contained I and II, suggesting that there is an age-dependent formation of the β-carboline skeleton in human lens. Preliminary experiments suggested 1,2,3,4-tetrahydro-β-carboline 1,3-dicarboxylic acid (V) and its 1-Me derivative (VI) are the in vivo precursors of IV and III, resp. The experimental part of the paper was very detailed, including the reaction process of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Application of 59132-30-8)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Application of 59132-30-8They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gatta, Franco; Misiti, Domenico published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Sodium periodate oxidation of tetrahydro-β-carboline derivatives》.Computed Properties of C13H12N2O4 The author mentioned the following in the article:

The oxidation of some 3-(methoxy- and ethoxycarbonyl)tetrahydro-β-carboline derivatives with sodium periodate led to the formation of 1,4-benzodiazonine derivatives e.g. I, or fully aromatic β-carbolines depending on both nature and number of substituents at 1-position. After reading the article, we found that the author used 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Computed Properties of C13H12N2O4)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Computed Properties of C13H12N2O4They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 59132-30-8On May 9, 1980 ,《Electrochemistry of natural products. 7. Oxidative decarboxylation of some tetrahydro-β-carbolinecarboxylic acids》 appeared in Journal of Organic Chemistry. The author of the article were Bobbitt, James M.; Willis, John P.. The article conveys some information:

A series of 1,2,3,4-tetrahydro-β-carboline-1- and -3-carboxylic acids containing various substituents in positions 1, 2, and 3 were oxidized electrochem. In general, the acids were decarboxylated, and unsaturation was introduced into the C ring. The oxidation appears to take place through the indole ring, N, and possible mechanisms of the reactions are given. Parallels between the observed reactions and early steps in indole alkaloid biosynthesis are discussed. The oxidative dimerization of tetrahydrocarbazole is reported. The experimental process involved the reaction of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8SDS of cas: 59132-30-8)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.SDS of cas: 59132-30-8They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Valin, Nathan; Haybron, David; Groves, Linda; Mower, H. F. published their research in Mutation Research, Genetic Toxicology Testing on December 31 ,1985. The article was titled 《The nitrosation of alcohol-induced metabolites produces mutagenic substances》.Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid The article contains the following contents:

The results of mutagen testing of reaction mixtures of nitrite and representative structures of tetrahydro-β-carbolines, tetrahydroisoquinolines, and tryptophols using Salmonella typimimium strains TA100, TA98, and TA97A are presented. All reaction mixtures were pos. for mutagenicity for ≥1 strains except for the nitrosation mixtures of tetrahydroisoquinoline and 1-methyl-1-methoxycarbonyl-1,2,3,4-tetrahydro-β-carboline-HCl  [101372-78-5]. The highest mutagenic activity was observed with strain TA98 with the exception of the reaction mixture of 5-hydroxytryptophol  [154-02-9] which was more active with TA100. The results came from multiple reactions, including the reaction of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acidThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Diem, Stefanie; Gutsche, Birgit; Herderich, Markus published their research in Journal of Agricultural and Food Chemistry on December 31 ,2001. The article was titled 《Degradation of Tetrahydro-β-carbolines in the Presence of Nitrite: HPLC-MS Analysis of the Reaction Products》.Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid The article contains the following contents:

Motivated by the identification of numerous novel tetrahydro-β-carboline-carboxylic acids in food samples, the authors studied the reactions of tetrahydro-β-carbolines in the presence of nitrosating agents. The anticipated formation of nitroso derivatives from unsubstituted tetrahydro-β-carbolines, and from tetrahydro-β-carboline-3-carboxylic acids was indicated by HPLC-MS/MS anal. and validated by the characteristic product ion spectra of the resp. nitroso compounds In addition, oxidative decarboxylation resulted in formation of the corresponding dihydro-β-carbolines, and in the generation of the β-carbolines harman or norharman. Subsequently, the authors studied the reactivity of tetrahydro-β-carboline-1-carboxylic acids derived from the Pictet-Spengler condensation of indole amines with α-oxo acids. Again, in the presence of nitrosating agents the rapid disappearance of the starting material was obvious, but no nitroso derivatives could be observed Instead, further HPLC-MS/MS studies demonstrated that dihydro-β-carbolines were the major products of tetrahydro-β-carboline-1-carboxylic acids. Finally, the authors demonstrated that freshly isolated nitroso-precursors spontaneously decomposed to yield harman alkaloids. Thus, nitroso-tetrahydro-β-carbolines can represent intermediates involved in the generation of β-carbolines; the authors established a novel pathway for the formation of harman alkaloids from nutritional tetrahydro-β-carbolines. The experimental part of the paper was very detailed, including the reaction process of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acidThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles