With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.603-76-9,1-Methyl-1H-indole,as a common compound, the synthetic route is as follows.
603-76-9, To the 25 ml pressure reaction tube add dimethyl sulfoxide (2 ml),N-Methyl indole (39.3 mg, 0.3 mmol),ethyl trifluoropyruvate(102.0 mg, 0.6 mmol), Cuprous chloride (44.78 mg, 1.5 eq.), The reaction was magnetically stirred in an 80 C oil bath for 12 hours. After the reaction was completed, most of the solvent was distilled off under reduced pressure, and the remaining mixture was purified by column chromatography on petroleum ether / ethyl acetate (10: 1) as eluent to obtain the desired product, As a pale yellow solid, 57.9 mg, Yield 85%.
As the paragraph descriping shows that 603-76-9 is playing an increasingly important role.
Reference£º
Patent; Lishui College; Yan Guobing; Huang Dayun; He Ping; Cao Xihan; Zheng Wanbin; Ke Qiumin; Shen Xuqian; (5 pag.)CN106946758; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles