6052-68-2, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6052-68-2, Example 10; General procedure for the preparation of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylates; 1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid 9a (50mmol), methanol or ethanol (250ml) and thionyl chloride (10ml) were added into a 500 ml round-bottom flask. The mixture was refluxed for 1 to 2 h. After alcohol was evaporated in reduced pressure, 100ml cold water was added. The pH was adjusted to 9 with saturated NaHCO3 solution. Then the mixture was extracted with ethyl acetate. The organic phases were combined, washed with water and brine, dried over anhydrous sodium sulfate, filtered, concentrated in vacuum. Recrystallization was conducted with ethyl acetate. Examples 11 and 12 were treated according to the above procedures.; Example 11; Synthesis of methyl 1,2,3,4-tetrahydro-beta-carboline-3-carboxylate (9b): white solids were obtained, and the yield was 57%.
The synthetic route of 6052-68-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Xinjiang Huashidan Pharmaceutical Research Co., Ltd.; EP1634881; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles