Category: 608-07-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.608-07-1,2-(5-Methoxy-1H-indol-3-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 5-methoxytryptamine (1.0 g, 5.3 mmol), aldehyde (6.3 mmol) in CH2Cl2 (10 mL) was added trifluoroacetic acid (0.7 mL). The reaction mixture was stirred at room temperature until the disappearance of the reactants (monitored by TLC). Then, the reaction mixture was adjusted to pH 7-8 with saturated aqueous NaHCO3 solution and extracted with CH2Cl2 (3 x 10 mL). The combined organic layer was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate) to afford 1q-1w.

608-07-1, 608-07-1 2-(5-Methoxy-1H-indol-3-yl)ethanamine 1833, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Ziquan; Sun, Yan; Wang, Lilin; Chen, Xuan; Sun, Yanpei; Lin, Long; Tang, Yulin; Li, Fei; Chen, Dongyin; Tetrahedron Letters; vol. 60; 11; (2019); p. 800 – 804;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

608-07-1, 2-(5-Methoxy-1H-indol-3-yl)ethanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In an 5 ml RB flask with refluxing condensor were added a mixtureof 4-nitrobenzaldehyde (2a, 33 mg, 0.22 mmol, 1.1 equiv.,), tryptamine(1a, 32 mg, 0.20 mmol, 1 equiv.,) in NMP (1 ml) under oxygen atmosphereand the resulting mixture was stirred at 140 C for 24 h. After thereaction was complete, the reaction mixture was concentrated underreduced pressure using rotary evaporator. The crude product thus obtainedwas purified by flash column chromatography on silica gel usingmixture of hexane-ethyl acetate (70:30) as eluent to obtain the product6a as Yellow solid; 91% yield (53.3 mg, 0.182 mmol); mp:244-246 C(Lit.20: 243-246 C);.

608-07-1, As the paragraph descriping shows that 608-07-1 is playing an increasingly important role.

Reference£º
Article; Ramu; Srinath; kumar, A. Aswin; Baskar; Ilango; Balasubramanian; Molecular catalysis; vol. 468; (2019); p. 86 – 93;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles