610794-15-5, 4-Bromo-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
610794-15-5, 4-Bromo-5-methylindole (0.7 g, 3.35 mmol), bis(pinacolato)diboron (1.7 g, 6.7 mmol), KOAc (1 g, 10 mmol) and Pd(dppf)Cl2 (73 mg, 3 mol %) were suspended in dry DMSO (20 mL) in two 40 mL glass tubes which were tightly sealed with an aluminium/Teflon crimp. The samples were irradiated at 250 W, 180 C. for 40 min in a CEM-Discover mono-mode microwave reactor. After completion of the reactions, the vessels were cooled down to 60 C., combined and the crude mixture was filtered through a thin plug of celite. The celite plug was washed with EtOAc (50 mL), the organic fractions were combined and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography and then prep-HPLC to give 5 (280 mg, 33%). 1H NMR CDCl3400 MHz delta 1.41 (s, 12H), 2.63 (s, 3H), 6.96-6.97 (m, 1H), 7.01-7.03 (m, 1H), 7.18-7.20 (m, 1H), 7.32-7.34 (m, 1H), 8.13 (s, 1H)
As the paragraph descriping shows that 610794-15-5 is playing an increasingly important role.
Reference£º
Patent; SAREUM LIMITED; Reader, John Charles; US2015/18367; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles