Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Sun, Linhao, once mentioned the application of 635-93-8, Name is 5-Chloro-2-hydroxybenzaldehyde, molecular formula is C7H5ClO2, molecular weight is 156.5664, MDL number is MFCD00003331, category is indole-building-block. Now introduce a scientific discovery about this category, Name: 5-Chloro-2-hydroxybenzaldehyde.
An electrochemically induced tandem reaction has been developed for selective N1-alkylation and C3-halogenation of indoles. This electrochemical difunctionalization strategy circumvents conventional multi-step procedures and efficiently generates synthetically important N-alkyl-3-halo-indoles under more environmentally benign conditions. This reaction can proceed in a simple undivided cell, without the use of any oxidant, base or transition-metal. The excellent atom-economy of this method is highlighted by fully using alkyl halide as both alkylating and halogenating building blocks without atom waste.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles