Category: 65417-22-3

Wender, Paul A.; Cooper, Christopher B. published an article in 1986, the title of the article was The photochemistry of 1-alkenylbenzotriazoles. Methodology for the synthesis of indoles.Related Products of 65417-22-3 And the article contains the following content:

Indoles I [R = (CH2)3OSiMe2CMe3, R1 = H; R = H, R1 = (CH2)3OSiMe2CMe3; R = Me, R1 = CO2Me; RR1 = (CH2)3, (CH2)4] were prepared by photolysis of 1-alkenylbenzotriazoles II. The 2,3-dihydropyrrolo[1,2-a]indole nucleus of the mitomycin antitumor antibiotics was prepared by desilylating I [R = (CH2)3OSiMe2CMe3, R1 = H], tosylating the alc., and ring closure of the tosylate. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Related Products of 65417-22-3

The Article related to indole, pyrroloindole mitomycin preparation, alkenylbenzotriazole preparation photolysis, benzotriazole alkenyl photolysis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 14, 2004, Nobayashi, Eiji; Fujii, Katsuhiro published a patent.Category: indole-building-block The title of the patent was Preparation of high-purity indolecarboxylic acids from their esters. And the patent contained the following:

Title carboxylic acids are prepared by hydrolysis of their esters I [R1-R6 = H, halo, alkyl, acyl(oxy), alkoxy, aryl, NO2, cyano, etc.; ≥1 of R1-R6 = carboxylic acid ester residue; R7 = H, C1-4 alkyl] with alkali metal hydroxides in nonpolar solvents, H2O, and alcs. Thus, Et 1-methylindole-2-carboxylate was treated with 4.8% aqueous NaOH at 55-59° in MePh and MeOH for 3 h, the organic phase removed, and acidified to give 95% 1-methylindole-2-carboxylic acid with 99.0% purity. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Category: indole-building-block

The Article related to indolecarboxylic acid preparation solvent nonpolar alc water, toluene methanol water solvent hydrolysis indolecarboxylate ester, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 30, 1977, Bergman, Jan; Carlsson, Rene; Sjoberg, Birger published an article.Safety of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was The reaction of indole and the indole Grignard reagent with phosgene. A facile synthesis of indole-3-carboxylic acid derivatives. And the article contained the following:

Indole-3-carboxylic and indole-3-glyoxylic acid derivatives were prepared from indoles or oxindoles and phosgene or oxalyl chloride. In this reaction, the indole Grignard reagent gave several products, including the cyclotetramers I (X = CO, COCO). Indolo-fused heterocycles were also prepared by this reaction. Thus, phosgene and 2-(2-hydroxyphenyl)-N-methylindole gave 5,6-dihydro-11-methyl-6-oxobenzo[a]pyrano[4,3-b]indole (II). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Safety of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole reaction phosgene, oxindole reaction phosgene, oxalyl chloride reaction indole, grignard indole phosgene, benzopyranoindole, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Michell, Glynn; Rees, Charles W. published an article in 1987, the title of the article was Photolysis of 1-aryl-1,2,3-triazoles; rearrangement via 1H-azirines.Name: Methyl 2-methyl-1H-indole-3-carboxylate And the article contains the following content:

Naphthyltriazoles I (R = H, Me; R1, R2 = H, Me, MeC:CH2, CO2Me, CO2Et, CHO, cyano; R1 = R2 = COPh, CO2Me, CONH2, cyano) 1 were prepared from 1-azidonaphthalenes by 1,3-dipolar cycloaddition reactions. Photolysis of I (R = H, R1 = R2 = COPh, CO2Me, CONH2, cyano; R1 = CO2Et, CO2Me, cyano; R2 = H, Me) gave good yields of the expected benz[g]indoles II. I (R = H, R1 = H, Me, R2 = CO2Et, CO2Me, cyano) also gave mixtures of the expected II and rearranged II. Photolysis of 1-phenyltriazoles III (R = H, Me; R1 = CO2Me; R = CO2Me, R1 = H, Me) gave similar results; III (R = CO2Me R1 = H, Me) gave mixtures of expected and rearranged indoles IV (R = CO2Me, R1 = H, Me; R = H, Me; R1 = CO2Me) whereas III (R = H, Me; R1 = CO2Me) gave indoles IV (R = H, Me, R1 = CO2Me) only. These results are explained by a mechanism in which the less stable carbene intermediate rearranges to the more stable carbene intermediate via a 1H-azirine intermediate, in competition with its direct cyclization. Photolysis of I (R = Me, R1 = R2 = CO2Me, cyano) follows a different salts, giving high yields of deeply colored benzoquinoline derivatives V (R1 = CO2Me, cyano). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to naphthyltriazole preparation photolysis, benzindole, indole, benzoquinoline, triazole aryl photolysis, azirine intermediate aryltriazole photochem rearrangement, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 2, 2018, Huang, Qi; Zard, Samir Z. published an article.Related Products of 65417-22-3 The title of the article was Inexpensive Radical Methylation and Related Alkylations of Heteroarenes. And the article contained the following:

A simple method for the introduction of a Me and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-Me pyrrolidone in a microwave oven. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Related Products of 65417-22-3

The Article related to heteroarene radical alkylation, alkylated heteroarene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yang, Qing-Qing; Marchini, Marianna; Xiao, Wen-Jing; Ceroni, Paola; Bandini, Marco published an article in 2015, the title of the article was Visible-Light-Induced Direct Photocatalytic Carboxylation of Indoles with CBr4/MeOH.Product Details of 65417-22-3 And the article contains the following content:

Photocatalysis enables the cascade reactions of indoles and CBr4 in MeOH through a C(sp2)-H functionalization/methanolysis sequence. The title reaction provides an efficient access to indole-2- and 3-carboxylates in a single operation (no preinstallation of protecting or directing groups was required) with good yields under mild reaction conditions. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3

The Article related to regioselective photocatalytic carboxylation indole tetrabromomethane methanol, carboxylation, indole functionalization, methanolysis, photocatalysis, visible light, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 16, 2019, Khan, Faiyaz; Fatima, Mehvish; Shirzaei, Moheb; Vo, Yen; Amarasiri, Madushani; Banwell, Martin G.; Ma, Chenxi; Ward, Jas S.; Gardiner, Michael G. published an article.Application of 65417-22-3 The title of the article was Tandem Ullmann-Goldberg Cross-Coupling/Cyclopalladation-Reductive Elimination Reactions and Related Sequences Leading to Polyfunctionalized Benzofurans, Indoles, and Phthalanes. And the article contained the following:

On exposure to a combination of Cu[I]- and Pd[0]-based catalysts, compounds such as halophenols and halocycloalkenones engage in tandem Ullmann-Goldberg cross-coupling and cyclopalladation-reductive elimination reactions to give benzofurans. Related reactions involving hetero-Michael additions of o-halogenated phenols or anilines to propiolates and the Pd[0]-catalyzed cyclization of the resulting conjugates provide, in a one-pot process, alternately functionalized benzofurans, indoles, or phthalanes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Application of 65417-22-3

The Article related to halophenol haloenone ullmann goldberg cross coupling cyclopalladation reductive elimination, benzofuran preparation, indole preparation, phthalane preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 30, 2002, Yamazaki, Kazuo; Kondo, Yoshinori published an article.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Palladium-Catalyzed Synthesis of Indole-3-Carboxylates on a Solid Polymer Support. And the article contained the following:

The indolecarboxylates I (R = H, Me; R1 = H, 5-Me, 6-F3C, 6-O2N) were prepared via Pd-catalyzed cyclization of the resin-bound enamino esters II (X = iodo, Br; Q = hydroxymethyl polystyrene resin) and subsequent NaOMe promoted resin cleavage. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to solid polymer support indolecarboxylate preparation, indolecarboxylate preparation, palladium catalyst enamino ester solid phase cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 31, 2007, Tanimori, Shinji; Ura, Haruna; Kirihata, Mitsunori published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles. And the article contained the following:

The copper-catalyzed one-step synthesis of 2,3-disubstituted indoles I (R = Me, Et, tert-Bu, Me2C:CHCH2CH2, etc., R1 = Me; R = Ph, 2-naphthyl, 2-furyl, 2-thienyl, 2-pyridyl, R1 = Et) from readily available starting materials, 2-iodoaniline and various β-keto esters was described. The advantage of this method is the use of cheap catalysts and simple exptl. procedures under mild reaction conditions. As the substituted indole derivatives are important starting materials for the synthesis of biol. active indole alkaloids and drug candidates, this method would have potential usage for these purposes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to iodoaniline keto ester copper binol ullmann coupling heterocyclization, indole alkoxycarbonyl preparation, alkoxycarbonylindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 2, 2018, Huang, Qi; Zard, Samir Z. published an article.Related Products of 65417-22-3 The title of the article was Inexpensive Radical Methylation and Related Alkylations of Heteroarenes. And the article contained the following:

A simple method for the introduction of a Me and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-Me pyrrolidone in a microwave oven. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Related Products of 65417-22-3

The Article related to heteroarene radical alkylation, alkylated heteroarene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles